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San Diego: Exploring the Role of APP in Transit

RESEARCH NEWS 2007-12-06 Research News At this year’s Society for Neuroscience annual meeting, held 3-8 November in San Diego, California, a special ancillary symposium called “Function of APP Gene Family Members and Clues to AD Pathogenesis: Studies from Worms to Mammals” ...

Genetic Risk Explained: Cystatin C Staves Off Plaque Formation in Mice

RESEARCH NEWS 2007-11-29 Research News On the one hand, research studies have amassed a laundry list of factors that influence experimental amyloid deposition in mouse models of amyloidosis. Almost everyone’s favorite molecule appears to tweak this readout, to the point where ...

San Diego: Oligomers Live Up to Bad Reputation, Part 3

CONFERENCE COVERAGE 2007-11-20 Conference Coverage A Direct Comparison 20 November 2007. A major point of confusion in this field has been that different research groups are working with different kinds of Aβ oligomer. The sources, the methods, and the tools used to characterize them ...

Aβ Oligomers—Small Steps in Detection, Characterization

RESEARCH NEWS 2007-11-01 Research News Since they were discovered to be a major toxic species, Aβ oligomers have haunted many a research lab. Their presence is difficult to detect in vivo and their full range of toxicities unclear. In the October 22 Journal of Neurochemistry ...

Tau Vaccine Detangles Mouse Brain

RESEARCH NEWS 2007-08-27 Research News Vaccination is not just for amyloid anymore, according to new work out this week from Einar Sigurdsson and colleagues at the New York University School of Medicine in New York. In the August 22 Journal of Neuroscience, the researchers report ...

Stress Granules: No Incubator for Inclusions, After All?

RESEARCH NEWS 2019-03-01 Research News TDP-43 proteinopathy rears its ugly head in most patients with amyotrophic lateral sclerosis and nearly half of those with frontotemporal dementia, not to mention many cases of Alzheimer’s disease and traumatic brain injury. Still, it’s been ...

A NAC1 for Recruiting the UPS to Dendritic Spines

RESEARCH NEWS 2007-08-16 Research News Dysfunction of the ubiquitin-proteasome system (UPS), by which cells dispose of defective proteins, is gaining attention as a mechanism leading to neurodegeneration. Suppression of the UPS led to Parkinson-like behaviors and neuropathology ...

Glaucoma, AD of the Eye?

RESEARCH NEWS 2007-08-10 Research News Glaucoma and Alzheimer disease (AD) might share more than being chronic, age-related diseases with devastating neurodegeneration. Some epidemiological evidence reveals that AD patients are almost three times more likely to have glaucoma than ...

Parkinson Disease—Potential Targets, Therapies

RESEARCH NEWS 2007-07-15 Research News The basic understanding of Parkinson disease, the second most common neurodegenerative disorder after Alzheimer’s, is growing and with it comes new therapeutic targets and potential treatments. In just the last few weeks researchers have ...

ApoE—Breaking Ties to Aβ Offers Potential Therapy

RESEARCH NEWS 2006-12-10 Research News The human ApoE4 isoform is the biggest single risk factor for sporadic Alzheimer disease (AD). Through direct interaction with Aβ, ApoEs promote clearance of Aβ across the blood brain barrier (see, for example, Shibata et al., 2000), but ...

Paper Alert: Nipping Tau Tangles in the Bud

RESEARCH NEWS 2006-09-07 Research News Just as amyloid-β toxicity may be attenuated by proteases such as insulin degrading enzyme and neprilysin, tau toxicity may be circumvented by the highly conserved puromycin-sensitive aminopeptidase (PSA)—at least in fruit flies. Alzforum ...

What Role BDNF?—A Question of Maturity

RESEARCH NEWS 2005-08-01 Research News In life, you wouldn’t trust a child to do an adult’s job. In the brain, the same might be true. While the mature form of brain-derived neurotrophic factor (BDNF) may stimulate long-term potentiation (LTP), or the strengthening of synaptic ...

SfN: Where, How Does Intraneuronal Aβ Pack Its Punch? Part 1

CONFERENCE COVERAGE 2005-12-01 Conference Coverage The story of intraneuronal Aβ, for years that of a few researchers calling into the wind, has generated a steady buzz at the 35th Annual Meeting of the Society for Neuroscience, held November 12-16 in Washington, D.C. Until recently, ...

SfN: Where, How Does Intraneuronal Aβ Pack Its Punch? Part 3

CONFERENCE COVERAGE 2005-12-02 Conference Coverage This is the third installment of a four-part news series about intraneuronal Aβ from the 35th Annual Conference of the Society for Neuroscience, held November 12 to 16 in Washington, D.C. See also Introduction and Part 1, Part 2, and ...

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