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At CTAD, Tau PET Emerges as Favored Outcome Biomarker for Trials

CONFERENCE COVERAGE 2017-12-08 Conference Coverage At the Clinical Trials on Alzheimer’s Disease meeting held November 1–4 in Boston, tau PET emerged as the crowd favorite among candidate biomarkers for measuring progression, in both natural history studies and future trials. It’s no ...

Neurofilament Light: A Universal Mark of Neurodegeneration

RESEARCH NEWS 2018-12-07 Research News A paper in the December 3 JAMA Neurology adds yet more evidence that neurofilament light (NfL) protein is a general biomarker of neurodegeneration. Scientists led by Bob Olsson and Erik Portelius, University of Gothenburg, Sweden, found ...

First Round of Awards from Chan Zuckerberg Initiative Announced

COMMUNITY NEWS 2018-12-07 Community News Earlier this year, the Chan Zuckerberg Initiative (CZI) dove into the field of neurodegenerative disease research, launching the Neurodegenerative Challenge Network to promote cross-disciplinary basic science research (Feb 2018 news). On ...

Pig Model of ALS Mimics Human Disease

RESEARCH NEWS 2018-11-30 Research News In the November 21 Neurobiology of Disease, researchers led by Cristiano Corona, Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d’Aosta, Turin, Italy, characterize the ALS-like signs and symptoms seen in pigs that ...

How Immune Cells From Blood Beget Aging in Brain

CONFERENCE COVERAGE 2018-12-14 Conference Coverage Never mind the wrinkles and gray hair. Embattled microglia, waning neurogenesis, and withering synapses are also part and parcel of the aging process. What drives those seemingly inexorable changes inside the brain? At the Society for ...

How Does The NIA-AA Framework Measure Up Against Real Data?

CONFERENCE COVERAGE 2018-11-19 Conference Coverage This past spring, the National Institute on Aging and Alzheimer’s Association proposed a new research framework in an effort to nudge the field toward a biological definition of Alzheimer’s disease (Apr 2018 news). The framework ...

World Dementia Council Takes Stock of Progress, Challenges

CONFERENCE COVERAGE 2018-12-12 Conference Coverage On December 5, global leaders came together at the Wellcome Trust offices in London for a meeting of the World Dementia Council, the body charged with leading the global response to dementia and coordinating international efforts ...

Toxic Tau: Who Are You, and Where Are You From?

CONFERENCE COVERAGE 2018-12-20 Conference Coverage Part 1 of a two-part story. Click here for Part 2. Tau comes in many forms, and calls many locations home, both inside and outside of cells. Which is the one that wreaks damage to neurons, and where exactly does it reside? Researchers ...

When Glial Clocks Fall Out of Sync, Inflammation Ensues

CONFERENCE COVERAGE 2018-12-21 Conference Coverage The circadian clock—the body’s molecular timekeeper—is best known for tuning our sleep, metabolism, digestion, and body temperature to the cycles of dark and light. Yet it controls other functions, as well. At the Society for ...

Stem Cell Model Nails Link Between Tauopathy and GABAergic Dysfunction

RESEARCH NEWS 2018-12-21 Research News Many genetic variants that lead to neurodegenerative disease are rare, and so scientists cannot obtain enough brain tissue for mechanistic studies. Researchers led by Celeste Karch, Carlos Cruchaga, and Oscar Harari at Washington University ...

Could a Blood Test for Tau Diagnose Alzheimer’s Disease?

RESEARCH NEWS 2018-12-24 Research News Cerebrospinal fluid tau is an established Alzheimer’s disease biomarker, but efforts to develop a blood test for tau have been hampered by exceedingly low concentrations of the protein there. At least, until now, claims a paper published in ...

Does Epigenetic Modification by Aβ Offer New Take on Therapy?

RESEARCH NEWS 2012-03-07 Research News Recent failures of clinical trials targeting amyloid-β in mild to moderate Alzheimer’s disease (AD) have led to claims that the interventions are too little too late, and that irreversible damage had occurred in the brain. A March 1 article ...

Without TREM2, Plaques Grow Fast in Mice, Have Less ApoE

RESEARCH NEWS 2019-01-07 Research News A paper in the January 7 Nature Neuroscience reports that in mice lacking TREM2, Aβ extracts seed new plaques faster than they do in control mice. Scientists led by Christian Haass, Ludwig-Maximilians University, Munich, and Melanie Meyer ...

Imaging Inflammation: Can Glial PET Tracers Make a Mark?

RESEARCH NEWS 2012-04-27 Research News The burgeoning proliferation in glia during neuroinflammation could indicate disease course and the efficacy of potential medicines, if only doctors could actually see astrocytosis and microgliosis in the living nervous system. A team of ...

Deadline to Weigh In on New Biomarker Guidance Approaches

COMMUNITY NEWS 2019-01-18 Community News The development of biomarkers for Alzheimer’s and other neurodegenerative diseases is accelerating rapidly, with blood tests and new fluid and imaging markers on the horizon (Aug 2018 news; Nov 2018 news; Dec 2018 news). However, developers ...

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