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Neurogenin Suppresses Astrocyte Differentiation

RESEARCH NEWS 2001-02-07 Research News Stem cell researchers know only too well that most adult neural precursor cells differentiate into astrocytes, not the coveted nerve cells. Even when stimulated by the addition of neuron-inducing growth factors, such as PDGF or NT-3, only a ...

Neprilysin Steps out of the Shadows

RESEARCH NEWS 2001-02-06 Research News The enzyme neprilysin-capable of degrading Aβ42 peptide-is a new player in the Alzheimer's disease mystery. Writing in Neuroscience Letters, Patrick McGeer's group at the University of British Columbia adds critical circumstantial ...

Study Finds Treatments for Agitation Are Inadequate

RESEARCH NEWS 2001-02-06 Research News The drugs haloperidol or trazodone, or behavior management techniques (BMT), are commonly used to treat agitation in Alzheimer's patients, but the first large-scale, randomized placebo-controlled study of such treatments has found that ...

Glia May Regulate Synaptic Formation and Transmission

RESEARCH NEWS 2001-01-26 Research News Glial cells quietly play a much bigger role than ever imagined, according to an article in today's issue of Science. Ben Barres and colleagues at Stanford in California report that astrocytes exert a powerful influence on communication ...

Part II: News Summary from American Society for Cell Biology Meeting

CONFERENCE COVERAGE 2001-01-19 Conference Coverage ADF/Cofilin Inclusions in Alzheimer's Disease James Bamburg presented a poster (Abstract 2821) on the formation of cellular inclusions composed of actin-depolymerizing factor (ADF) and the cofilin family of proteins (collectively ...

GFAP Mutation in Alexander's Disease

RESEARCH NEWS 2001-01-17 Research News The cause of Alexander's disease, a very rare, inherited CNS disorder, has been traced to the gene for glial fibrillary acidic protein (GFAP), according to a report published in this month's Nature Genetics. The disease results in ...

Trio of Papers Report Chromosome 10 Linkage

RESEARCH NEWS 2001-01-11 Research News Three independent studies published in the 22 December issue of Science reported that chromosome 10 probably harbors one or more genes that confer an increased susceptibility to late-onset Alzheimer's disease. The specific gene or genes ...

Symposium: Gene Expression Profiling of Alzheimer's Disease

CONFERENCE COVERAGE 2001-01-08 Conference Coverage Annual Meeting of the American College of Neuropsychopharmacology, San Juan, Puerto Rico. At this meeting, the speakers discussed the sequence of changes in gene expression in the brain that may take place during the transition from ...

Selegiline Does Not Increase Parkinson's Death Rate

RESEARCH NEWS 2000-12-23 Research News The drug selegiline, thought to be neuroprotective, has been used to treat Parkinson's disease for the past 25 years, but a report a few years ago suggested that the drug could accelerate death in patients taking it. A new study from ...

New DNA Array Method Paves Way to "User's Manual" for Master Genes

RESEARCH NEWS 2000-12-22 Research News In today's issue of Science, researchers at the Whitehead Institute and Corning Inc. describe a new microarray technique that can decipher the function of master switches in a cell by identifying the set of genes they control across the ...

Blocking Aβ's Oxygen Radical Producing Power

RESEARCH NEWS 2000-12-21 Research News A study presented earlier this week at the 2000 International Chemical Congress of Pacific Basin Societies in Honolulu found that by manipulating the structure of amyloid-β, it was possible to reduce the peptide's ability to induce the ...

More Vaccine Results in Nature

RESEARCH NEWS 2000-12-20 Research News A trio of articles will appear in tomorrow's issue of Nature, reporting that Aβ peptide immunization reduces a memory deficit in transgenic mouse models of AD. The findings from the University of Toronto and University of South Florida ...

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