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Presenilins Open Escape Hatch for ER Calcium

RESEARCH NEWS 2006-09-09 Research News A paper out today in Cell proposes a novel role for presenilins in calcium signaling—that of an ion channel. The work, from Ilya Bezprozvanny and colleagues at the University of Texas Medical Center at Dallas, shows that presenilins appear ...

APP Double Dose Causes Early Onset AD

RESEARCH NEWS 2005-12-20 Research News For the first time, researchers have identified duplications of the amyloid precursor protein (APP) gene locus as the cause of early onset Alzheimer disease in five families. The findings, from the laboratory of Dominique Campion of INSERM ...

Chicago: Out of the Blue—A Tau-based Treatment for AD?

CONFERENCE COVERAGE 2008-08-07 Conference Coverage Of all clinical trials reported at the International Conference on Alzheimer’s Disease (ICAD) held 26-31 July in Chicago, one targeting the protein tau was the therapy du jour, both in terms of buzz among scientists and media coverage. ...

Alzheimer’s Vaccine: In Some Patients, at Least, It Might Just Work

RESEARCH NEWS 2003-05-21 Research News After a tough year, during which believers in immunotherapy for Alzheimer’s disease have had to fend off vociferous criticism, the news now appears to pick up. In tomorrow’s Neuron, Swiss researchers announce that among the AD patients who ...

Los Angeles: People With Memory Loss Speak for Themselves

CONFERENCE COVERAGE 2007-10-29 Conference Coverage On Saturday, 27 October, in Los Angeles, an unusual conference marked a paradigm shift in the Alzheimer disease movement, or so its organizers hope and vow. Put together jointly by Richard Bozanich (see ARF Q&A) and Jay Smith, two ...

Larry Sparks, of Alzheimer’s-Cholesterol Fame, Dies at 63

COMMUNITY NEWS 2013-05-18 Community News Alzheimer's disease researchers expressed sadness this week at the sudden death of Larry Sparks, senior scientist at the Banner Sun Health Research Institute, Sun City, Arizona, at the age of 63. Sparks worked in Sun City from 1997. ...

GSAP Revisited: Does It Really Play a Role in Processing Aβ?

RESEARCH NEWS 2014-01-03 Research News In Alzheimer’s research, finding a way to safely lower Aβ levels in the human brain remains a central goal. Thus, scientists were excited by a 2010 Nature paper in which researchers led by Nobel laureate Paul Greengard at Rockefeller ...

Pathogenic Presenilin Mutations Generate Aβ43

RESEARCH NEWS 2016-04-29 Research News Papers in the March 17 EMBO Molecular Medicine and the April 20 Neuron have reignited a simmering debate about the role of presenilin mutations in familial Alzheimer’s disease. Both studies dispute a claim made previously by Jie Shen, Ray ...

Lodged in Late Endosomes, Presenilin 2 Churns Out Intraneuronal Aβ

RESEARCH NEWS 2016-06-10 Research News Presenilin 2 has long lived in the shadow of its sibling, presenilin 1. Either one can serve as the catalytic subunit of γ-secretase, but presenilin 1 has hogged much of the limelight, in part because many more pathogenic Alzheimer’s disease ...

Merck Pulls Plug on Phase 2/3 BACE Inhibitor Trial

RESEARCH NEWS 2017-02-15 Research News Merck dropped a Valentine’s Day downer announcing they will stop the EPOCH trial of verubecestat  in mild to moderate Alzheimer’s disease. A prespecified interim analysis by an external data-monitoring committee gave the trial “virtually no ...

Semagacestat, a Pseudo γ-Secretase Inhibitor?

RESEARCH NEWS 2017-10-12 Research News Seven years after semagacestat failed in Phase 3 clinical trials for Alzheimer’s disease, researchers led by Masayasu Okochi at Osaka University, Japan, offer a new reason why. In the October 3 Cell Reports, the scientists claim that the γ ...

Gaining Notoriety, SORL1 Claims Spot Among Top Alzheimer’s Genes

RESEARCH NEWS 2018-06-07 Research News In the complex genetics of Alzheimer’s, only a handful of genes by themselves have a massive impact on risk. ApoE4 and TREM2 boost a person’s odds of late-onset AD from three- to 12-fold, and the three autosomal-dominant genes APP, PS1, and ...

Lymphatic Brain Drain Withers in Aging, Worsens Disease

RESEARCH NEWS 2018-07-27 Research News In recent years, scientists have characterized a hidden set of lymphatic vessels in the meninges, the membranes that line the skull and envelope the brain (Oct 2017 news). These meningeal lymphatic vessels carry waste from the cerebrospinal ...

Immunotherapy Update: Toward Patches and Creams

RESEARCH NEWS 2007-01-25 Research News In the future, could Alzheimer disease treatments come as an ointment, or a skin patch? That may not be as far out as it seems, with a new study published this week in PNAS online showing that mice produce amyloid-clearing antibodies after ...

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