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Anatomy News Flash: Brain Drains Lymphatic Fluid Through Its Base

RESEARCH NEWS 2019-07-26 Research News The 2015 discovery of lymphatic vessels in the brain’s meninges threw open a door to seeing how this still-mysterious organ clears waste. Subsequent work showed that these vessels, which reside in the brain’s outermost membrane, the dura ...

A Central Role for Prion Protein in Neurodegeneration?

RESEARCH NEWS 2020-02-06 Research News Like Aβ oligomers, soluble aggregates of tau and α-synuclein bind to cellular prion protein, poisoning neurons, according to a study published in Acta Neuropathologica. Using a standardized procedure to produce soluble aggregates of these ...

Lithium Hinders Aβ Generation, Buffing Up GSK as Drug Target

RESEARCH NEWS 2003-05-22 Research News The widely used psychiatric drug lithium, and other agents that inhibit glycogen synthase kinase-3 (GSK3), have been mentioned as possible Alzheimer's disease therapies for some time, primarily because GSK3 is one of several kinases ...

Atorvastatin, Vaccine Trial Data Published

RESEARCH NEWS 2005-05-13 Research News A mixed bag of epidemiologic studies alternatively hold up and knock down the promise that widely prescribed cholesterol-lowering statin drugs might offer some protection against Alzheimer disease progression (see ARF related news story). ...

Love a Good Fight? Check Out Brouhaha Over Amyloid Imaging

COMMUNITY NEWS 2012-02-02 Community News See Q&A With Bengt Långström The ability to visualize fibrillar Aβ deposits in the brains of living people has been hailed as a breakthrough for Alzheimer’s disease research and differential diagnosis. Now, as the first of a suite of ...

Presenilins Open Escape Hatch for ER Calcium

RESEARCH NEWS 2006-09-09 Research News A paper out today in Cell proposes a novel role for presenilins in calcium signaling—that of an ion channel. The work, from Ilya Bezprozvanny and colleagues at the University of Texas Medical Center at Dallas, shows that presenilins appear ...

APP Double Dose Causes Early Onset AD

RESEARCH NEWS 2005-12-20 Research News For the first time, researchers have identified duplications of the amyloid precursor protein (APP) gene locus as the cause of early onset Alzheimer disease in five families. The findings, from the laboratory of Dominique Campion of INSERM ...

Chicago: Out of the Blue—A Tau-based Treatment for AD?

CONFERENCE COVERAGE 2008-08-07 Conference Coverage Of all clinical trials reported at the International Conference on Alzheimer’s Disease (ICAD) held 26-31 July in Chicago, one targeting the protein tau was the therapy du jour, both in terms of buzz among scientists and media coverage. ...

Alzheimer’s Vaccine: In Some Patients, at Least, It Might Just Work

RESEARCH NEWS 2003-05-21 Research News After a tough year, during which believers in immunotherapy for Alzheimer’s disease have had to fend off vociferous criticism, the news now appears to pick up. In tomorrow’s Neuron, Swiss researchers announce that among the AD patients who ...

Los Angeles: People With Memory Loss Speak for Themselves

CONFERENCE COVERAGE 2007-10-29 Conference Coverage On Saturday, 27 October, in Los Angeles, an unusual conference marked a paradigm shift in the Alzheimer disease movement, or so its organizers hope and vow. Put together jointly by Richard Bozanich (see ARF Q&A) and Jay Smith, two ...

Larry Sparks, of Alzheimer’s-Cholesterol Fame, Dies at 63

COMMUNITY NEWS 2013-05-18 Community News Alzheimer's disease researchers expressed sadness this week at the sudden death of Larry Sparks, senior scientist at the Banner Sun Health Research Institute, Sun City, Arizona, at the age of 63. Sparks worked in Sun City from 1997. ...

GSAP Revisited: Does It Really Play a Role in Processing Aβ?

RESEARCH NEWS 2014-01-03 Research News In Alzheimer’s research, finding a way to safely lower Aβ levels in the human brain remains a central goal. Thus, scientists were excited by a 2010 Nature paper in which researchers led by Nobel laureate Paul Greengard at Rockefeller ...

Pathogenic Presenilin Mutations Generate Aβ43

RESEARCH NEWS 2016-04-29 Research News Papers in the March 17 EMBO Molecular Medicine and the April 20 Neuron have reignited a simmering debate about the role of presenilin mutations in familial Alzheimer’s disease. Both studies dispute a claim made previously by Jie Shen, Ray ...

Lodged in Late Endosomes, Presenilin 2 Churns Out Intraneuronal Aβ

RESEARCH NEWS 2016-06-10 Research News Presenilin 2 has long lived in the shadow of its sibling, presenilin 1. Either one can serve as the catalytic subunit of γ-secretase, but presenilin 1 has hogged much of the limelight, in part because many more pathogenic Alzheimer’s disease ...

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