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Klotho Variant Cuts ApoE4’s Alzheimer Risk by a Third

RESEARCH NEWS 2020-04-17 Research News A meta-analysis of 22 cohorts seems to leave little doubt that variants of the longevity gene klotho protect against dementia—at least in people unfortunate enough to have inherited an ApoE4 allele. Researchers led by Michael Belloy, ...

‘Working from Home’: Do Gut Microbes Hold Sway Over Glia, Aβ?

CONFERENCE COVERAGE 2020-04-16 Conference Coverage At the virtual AAT-AD/PD meeting, held April 2 to 5 online, researchers substantiated some prior hints on potential causal connections between the throngs of bacteria inhabiting the gut, how microglia function in the brain, and ...

Does Alzheimer’s Start in the Heart of the Cholinergic System?

CONFERENCE COVERAGE 2020-04-16 Conference Coverage Three the approved drugs for Alzheimer’s disease attempt to boost the brain’s supply of acetylcholine, a critical neurotransmitter for cognition that wanes in people with the disease. But might crumbling of the brain’s cholinergic ...

Active Tau Vaccine: Hints of Slowing Neurodegeneration

CONFERENCE COVERAGE 2020-04-15 Conference Coverage Because cognition in Alzheimer’s disease declines as tangles spread, and tau research tools are finally in hand, researchers are increasingly homing in on tau immunotherapy. At the second biannual Advances in Alzheimer’s and Parkinson ...

Confused About the DIAN-TU Trial Data? Experts Discuss

CONFERENCE COVERAGE 2020-04-10 Conference Coverage At the virtual AAT-AD/PD Focus meeting held April 1 to 5, clinicians and funders involved in the Dominantly Inherited Alzheimer’s Network Trials Unit (DIAN-TU) fired up their home computers to discuss results from the first DIAN-TU ...

217—The Best Phospho-Tau Marker for Alzheimer’s?

CONFERENCE COVERAGE 2020-04-10 Conference Coverage A flood of recent data seems to leave little doubt that phospho-tau217 is the better of the soluble tau markers for studying Alzheimer’s disease thus far. At this year’s virtual AAT-AD/PD meeting, Oskar Hansson, Lund University, Sweden ...

New Assay, New Cohorts—Plasma p-Tau181 Looks Even Better

CONFERENCE COVERAGE 2020-04-03 Conference Coverage The conference may be virtual, but the data is real. At the online AAT-ADPD 2020, researchers presented their talks and posters in much that same way as they would have in person—albeit without the open question-and-answer time. Up ...

Low-Dose Aspirin Does Not Prevent AD, or Slow Cognitive Decline

RESEARCH NEWS 2020-04-01 Research News An aspirin a day does not keep dementia away. Nor does it hedge the risk of mild cognitive impairment or slow decline, according to results published March 25 in Neurology. Reasoning that the anti-inflammatory and cardiovascular health ...

A Phospho-Tau Plasma Assay for Alzheimer’s?

RESEARCH NEWS 2020-03-31 Research News Researchers stunned the field last summer when they reported that phosphorylated tau turns up in peoples’ plasma decades before they show signs of dementia. The data bore the promise of a blood test for early Alzheimer’s disease—one that is ...

A ‘Perfect Storm’ for Families Grappling with Dementia

COMMUNITY NEWS 2020-03-28 Community News As the COVID-19 pandemic engulfs the globe, it puts extraordinary strain on at-risk groups—very much including people with neurodegenerative disease and their carers. Not only do most people with neurodegenerative diseases fall into the age ...

Coronavirus Takes Its Toll on Alzheimer’s Clinical Studies

COMMUNITY NEWS 2020-03-27 Community News The coronavirus pandemic is upending not only life as we knew it, but Alzheimer’s clinical studies as well. In the United States, Europe, and Australia, most sites have put observational cohort studies on hold, and many have stopped dosing ...

Social Distancing Shutters Alzheimer’s Research

COMMUNITY NEWS 2020-03-27 Community News “Do what you can, with what you have, where you are.” Theodore Roosevelt. Globally the story is the same almost everywhere. Scientists are in lockdown, most staying at home as skeleton crews tend to the most crucial experiments and valuable ...

Dementia Research Institute to Double U.K. Coronavirus Testing

COMMUNITY NEWS 2020-03-24 Community News While science groups worldwide are grappling with the logistics of shutting down to comply with the social distancing required to slow the spread of COVID-19, neurodegenerative disease researchers are asking how they can help. And help they ...

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