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Widely Used Tau Seeding Assay Challenged

RESEARCH NEWS 2020-05-22 Research News Many research groups study tau misfolding and propagation using in vitro models, but interpreting findings from artificial systems can be dicey. In a preprint on bioRxiv, researchers led by Eckhard Mandelkow at the German Center for ...

Gut Microbes: The Difference Between Life and Death in C9ORF72 Mice

RESEARCH NEWS 2020-05-15 Research News When Kevin Eggan of Harvard University decided to raise some C9ORF72-deficient mice down the road at MIT’s Broad Institute, he had little inkling of the can of worms—or microbes—that he was about to open. At Harvard, the C9-deficient mice ...

Could Tau PET Replace Amyloid Biomarkers as a Diagnostic for AD?

RESEARCH NEWS 2020-05-15 Research News The particular type of tangle found in Alzheimer’s is unique to this disease, making tau PET a highly specific marker. In the May 11 JAMA Neurology, researchers led by Oskar Hansson at Skåne University Hospital in Malmö, Sweden, reinforce ...

Mouse Brain Mapped in 3D, at High Resolution

RESEARCH NEWS 2020-05-13 Research News Behold the mouse brain, in glorious new detail. In the May 14 Cell, researchers led by Julie Harris and Lydia Ng at the Allen Institute for Brain Science in Seattle debut the third iteration of the Allen Mouse Brain atlas. Called the Common ...

Even Without Amyloid, ApoE4 Weakens Blood-Brain Barrier, Cognition

RESEARCH NEWS 2020-05-09 Research News ApoE4 weakens the blood-brain barrier in the hippocampus, and in this way takes its toll on cognition, according to a study published April 29 in Nature. Researchers led by Berislav Zlokovic of the University of Southern California in Los ...

Herpes Simplex Virus Triggers Amyloidosis in 3D Neural Cultures

RESEARCH NEWS 2020-05-08 Research News Looking for a way to model the human brain in a dish? Consider using a gel-filled silk sponge as a three-dimensional scaffold to mimic the vaunted organ’s architecture. That, at least, is the approach published by David Kaplan at Tufts ...

Flortaucipir Autopsy Study Published

RESEARCH NEWS 2020-05-02 Research News Results from a large autopsy validation study suggest that flortaucipir PET can help clinicians diagnose late-stage Alzheimer’s disease. In the April 27 JAMA Neurology, researchers led by Adam Fleisher at Avid Radiopharmaceuticals/Eli Lilly, ...

Mutations in Epigenetic Gene Linked to Neurodegeneration

RESEARCH NEWS 2020-05-01 Research News Rare but powerful gene variants help scientists understand how disease develops, but they are hard to find. By pooling data on people with different early onset dementias to get cohorts of a workable size, researchers pulled out an ...

Paul Taylor Wins 2020 Potamkin Prize

COMMUNITY NEWS 2020-05-01 Community News In a virtual ceremony hosted by the American Brain Foundation on April 29, Potamkin Philanthropies awarded the 2020 Potamkin Prize for Research in Pick’s, Alzheimer’s, and Related Diseases to J. Paul Taylor from St. Jude Children’s Research ...

Sigh of Relief? Lung Effects of LRRK2 Inhibitors are Mild.

RESEARCH NEWS 2020-04-24 Research News Proponents of LRRK2 inhibitor programs may breathe easier following a paper in the April 22 Science Translational Medicine. A collaboration led by researchers at the Michael J. Fox Foundation found that three different inhibitors of this ...

α-Synuclein Antibody Misses Primary, May Have Signal on Secondaries

CONFERENCE COVERAGE 2020-04-22 Conference Coverage Roche and Prothena today announced  topline results from the first half of their Phase 2 trial of the α-synuclein antibody prasinezumab. Results were negative on the MDS-UPDRS, the primary outcome measure, but the company said it saw ...

Parkinson's Therapies Seek to Stem Progression

CONFERENCE COVERAGE 2020-04-22 Conference Coverage At the second biannual Advances in Alzheimer’s and Parkinson’s Therapies Focus Meeting (AAT-AD/PD), held virtually April 2 to 5, companies offered some news on investigational Parkinson’s therapies in Phase 1. One approach is targeted ...

With TREM2, Timing Is Everything

CONFERENCE COVERAGE 2020-04-22 Conference Coverage Certain variants in the TREM2 gene more than triple a person’s risk of AD, seemingly by sapping the protective function this microglial receptor performs. According to findings presented at the virtual AAT-AD/PD meeting, held April 2 ...

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