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Imaging Model Locates Epicenter of Disease, Predicts Atrophy

RESEARCH NEWS 2019-10-18 Research News In neurodegenerative diseases, specific brain regions take the brunt of pathology and atrophy. However, differences from one patient to another make it hard to predict the precise path of progression for any one person. Now, scientists led ...

Could Getting Enough REST Extend Your Life?

RESEARCH NEWS 2019-10-18 Research News Why do some people age better than others? In the October 16 Nature, researchers led by Bruce Yankner at Harvard Medical School once again credit the repressor element 1-silencing transcription factor (REST). People who lived to a ripe old ...

Tau Natively Unstructured? Not Always, New Study Says

RESEARCH NEWS 2019-10-17 Research News Researchers for years thought that tau was a natively unstructured protein. Then how in the world do its supposedly disordered monomers give rise to the orderly stacks of tau molecules seen in tau fibrils? Using chemical cross-linkers to ...

In Tauopathy, ApoE Destroys Neurons Via Microglia

RESEARCH NEWS 2019-10-17 Research News ApoE4 delivers a blow to neurons in mouse models of tauopathy but, according to a paper published October 10 in the Journal of Experimental Medicine, it only does so if mice have their microglia. Researchers led by David Holtzman at ...

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