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Paper Alert: VCAM1 Opens the Door to Brain Aging

RESEARCH NEWS 2019-05-18 Research News Mysterious factors in the blood are known to trigger aging in the brain. Though researchers have yet to discover the identities of all these aging agents, they have pegged a protein that lets them do their dirty work. On May 13 in Nature ...

BACE Inhibitors: Postmortem on One, Live Updates on Two

CONFERENCE COVERAGE 2019-05-17 Conference Coverage At the AD/PD 2019 conference held recently in Lisbon, the amyloid hypothesis was reeling from repeated gut punches in the clinic. Both antibodies and BACE inhibitors are facing relentless criticism from academic scientists and ...

Plasticity Hums With Protein Synthesis on Both Sides of Synapse

RESEARCH NEWS 2019-05-17 Research News Scientists know that synaptic plasticity requires local protein production from translation of mRNAs in postsynaptic dendrites. However, local synthesis had not been clearly demonstrated on the other, presynaptic side in mature axons. A new ...

Gamma Waves Synchronized by Light: Good for Synapses, Memory?

RESEARCH NEWS 2019-05-17 Research News If using flashing lights to treat Alzheimer’s disease sounds like science fiction, then brace yourself, because new data strengthen the case for this idea. Previously, Li-Huei Tsai and colleagues at MIT had reported that a treatment ...

WHO Weighs in With Guidelines for Preventing Dementia

COMMUNITY NEWS 2019-05-17 Community News Many researchers and advocacy groups tout the benefits of a healthy lifestyle for preventing cognitive decline and dementia. Now the World Health Organization has weighed in, releasing a set of guidelines for lowering risk. The guidelines ...

Keep Your Enthusiasm? Scientists Process Brutal Trial Data

CONFERENCE COVERAGE 2019-05-16 Conference Coverage “There is a lot of bad news, but it’s useful bad news.” This line by Randy Bateman of Washington University, St. Louis, captured the mood at the AD/PD conference held March 27 to 31 in Lisbon, Portugal. Whereas in years past scientists ...

Forget Fibrils: Lewy Pathology Is More Lipid Than Protein

CONFERENCE COVERAGE 2019-05-10 Conference Coverage In Parkinson’s disease, abnormal deposits called Lewy bodies and Lewy neurites pop up in neurons and processes, respectively. In 1998, Maria Grazia Spillantini at the University of Cambridge identified α-synuclein as their major ...

Do Immune Cells Promote the Spread of α-Synuclein Pathology?

CONFERENCE COVERAGE 2019-05-10 Conference Coverage How does α-synuclein pathology spread? At the 14th International Conference on Alzheimer’s and Parkinson’s Diseases, held March 27–31 in Lisbon, Portugal, speakers said immune cells bear some of the blame. Markus Britschgi of Roche in ...

Antibodies Against Microglial Receptors TREM2 and CD33 Head to Trials

CONFERENCE COVERAGE 2019-05-10 Conference Coverage As neuroinflammation becomes ever more deeply implicated in Alzheimer’s disease, therapies targeting this process are starting to enter clinical trials. At the 14th International Conference on Alzheimer’s and Parkinson’s Diseases, held ...

Drug Reported to Help Alzheimer’s Patients Sleep Better

CONFERENCE COVERAGE 2019-05-10 Conference Coverage Nearly half of people with Alzheimer’s can’t sleep at night, waking up more often and staying awake longer than others their age. This causes nighttime wandering, and worsens cognition and depression. Despite the burden for both ...

Longitudinal Tau-PET Links Aβ to Subsequent Rise in Cortical Tau

RESEARCH NEWS 2019-05-09 Research News The growth of tau tangle pathology in the brain’s cortex only happens in people who also have Aβ plaques, and it correlates with cognitive decline. These conclusions are supported by the largest, multicenter, longitudinal tau PET study ...

Amyloid-PET Results Lead Some to Ponder Assisted Death in Future

RESEARCH NEWS 2019-05-09 Research News As Alzheimer’s disease prevention studies are seeking cognitively healthy but biomarker-positive volunteers, researchers must grapple with ethical implications of divulging amyloid status to symptom-free people. What is the psychological ...

Off-Balance Endocytosis Lays Groundwork for Disease

CONFERENCE COVERAGE 2019-05-03 Conference Coverage Endocytosis is implicated in Alzheimer’s pathogenesis, because the continuous swallowing up of proteins from the cell surface and packaging them into little organelles brings the amyloid precursor protein (APP) into contact with the ...

Plasma NfL Goes the Distance in Alzheimer’s

RESEARCH NEWS 2019-05-02 Research News Damaged axons spill their guts, and the debris eventually makes its way into the bloodstream. Now, scientists tracking one such neuron-derived protein are moving closer to a blood test for neurodegeneration in Alzheimer’s disease. In a ...

Introducing LATE—A Common TDP-43 Proteinopathy that Strikes After 80

RESEARCH NEWS 2019-05-01 Research News An 86-year-old woman develops classic amnestic symptoms of Alzheimer’s disease in her last years of life, but upon autopsy, her brain bears but a modest burden of Aβ plaques and tau tangles. Instead, TDP-43 inclusions crowd her limbic ...

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