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Lysosomal Diseases: Stepping Stones to Gene Therapy for Alzheimer’s?

RESEARCH NEWS 2019-12-05 Research News Gene therapy has re-emerged as a potentially revolutionary treatment for familial and, eventually, sporadic, Alzheimer’s disease (Parts 2 and 3 of the Society for Neuroscience 2019 annual meeting series). While researchers are mulling over ...

Gene Therapies Enter Trials for Many Brain Pathologies—What about AD?

CONFERENCE COVERAGE 2019-11-28 Conference Coverage Buoyed by success in spinal muscular atrophy, scientists are once again devising gene-based therapies for neurodegeneration. Some are permanent, which makes proving their safety all the more challenging. Still, as shown at this year’s ...

Time to Try Again: Gene-Based Therapy for Neurodegeneration

CONFERENCE COVERAGE 2019-11-27 Conference Coverage Twenty years ago, researchers took fibroblasts from the skin of eight Alzheimer’s patients, engineered them to produce nerve-growth factor, and slid them into each volunteer’s basal forebrain. They hoped the neurotrophin would halt or ...

The Human Brain Hosts a Menagerie of Microglia

RESEARCH NEWS 2019-11-23 Research News For brain cells, what do aging, living in white matter, and hanging out with tumors have in common? If you’re a microglia, these all upset your homeostasis. On November 18 in Nature Neuroscience, researchers led by Marco Prinz of the ...

Microglia Inflammasome Stokes Tau Phosphorylation, Tangles

RESEARCH NEWS 2019-11-22 Research News Microglia have been firmly linked to amyloid plaques, but scientists are only beginning to examine their relationship to tau tangles. In the November 20 Nature, Michael Heneka and colleagues at the German Center for Neurodegenerative ...

Minocycline Does Not Work in Mild Alzheimer’s Disease

RESEARCH NEWS 2019-11-22 Research News Treatment with the antibiotic minocycline failed to slow cognitive decline or functional impairment in patients with mild Alzheimer’s disease, according to a November 18 paper in JAMA Neurology. Researchers led by Robert Howard, University ...

Cell-Specific Enhancer Atlas Centers AD Risk in Microglia. Again.

RESEARCH NEWS 2019-11-16 Research News Most GWAS hits lie in noncoding regions of the genome, making it hard to figure out what they do. To address this, researchers led by Christopher Glass at the University of California, San Diego, analyzed epigenetic data from purified ...

Dipeptide Repeat Proteins Don’t Directly Block Nuclear Transport

RESEARCH NEWS 2019-11-15 Research News Lots of evidence suggests dipeptide repeat proteins translated from hexanucleotide repeat expansions in C9ORF72 interfere with transport of proteins in and out of the cell’s nucleus. However, an October 31 paper in Scientific Reports ...

Already in Mid-30s, Poor Vascular Health Means Small Brain at 70

RESEARCH NEWS 2019-11-13 Research News Updated November 14, 2019 Thirty-somethings take heed. A new study suggests it’s time to take care of your vascular health. Using data from the longest continuously running birth cohort in the world, researchers led by Jonathan Schott of ...

Acetaminophen Derivative Tempers Microglia, Spurs Plaque Clearance

RESEARCH NEWS 2019-11-08 Research News Researchers are searching for ways to dampen harmful inflammation and boost microglial phagocytosis in the Alzheimer’s brain. In the November 4 Proceedings of the National Academy of Sciences, researchers led by Hee Kyung Jin and Jae-sung ...

Older Retired Soccer Players Prone to Neurodegeneration

RESEARCH NEWS 2019-11-08 Research News Former professional soccer players are more likely to develop a neurodegenerative disease than the general population, according to a November 7 paper in the New England Journal of Medicine. Researchers led by William Stewart, University of ...

Can an ApoE Mutation Halt Alzheimer’s Disease?

RESEARCH NEWS 2019-11-04 Research News In today’s Nature Medicine, a team of researchers led by Yakeel Quiroz, Joseph Arboleda-Velasquez, Francisco Lopera, and Eric Reiman describe the case of a Colombian woman who inherited the autosomal-dominant E280A mutation in presenilin 1 ...

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