TADPOLE Challenge: Winners Forecast AD Symptoms

COMMUNITY NEWS 2019-06-19 Community News Results are in for the TADPOLE Challenge—a prize contest that invited researchers to come up with their own ways of predicting dementia symptoms in participants enrolled in the Alzheimer’s Disease Neuroimaging Initiative (ADNI). In a live ...

Parsing Local and Distal Aβ Shows Links to Metabolism, Cognition

RESEARCH NEWS 2019-06-14 Research News For decades, researchers have wondered why Aβ deposits in the brain correlate poorly with local neural activity and cognition. Perhaps the correlation was not that weak, after all. A study in the June 4 Nature Communications suggests that it ...

Sliced by ApoE Genotype, Whole Exome Data Yield New AD Variants

RESEARCH NEWS 2019-06-14 Research News Does the head honcho of genetic Alzheimer’s risk occlude contributions of smaller genes? In the June 10 JAMA Neurology, researchers led by Lindsay Farrer at Boston University exposed some hidden variants that have languished in the shadow of ...

Study Strengthens Link between Hepatitis C Virus, Parkinson’s

RESEARCH NEWS 2019-06-13 Research News Epidemiology has tied infection with hepatitis C to an increased risk for Parkinson’s disease. But what happens when the infection is treated? By surveying medical records of nearly 200,000 patients, researchers led by Ying-Zu Huang and Rou ...

Dead Microglia Pave the Way for Myelin Regeneration

RESEARCH NEWS 2019-06-12 Research News In brain disease, microglia can be villains or heroes. How to encourage the latter? In the June 10 Nature Neuroscience, researchers led by Veronique Miron at the University of Edinburgh tried by killing off the troublemakers. In a mouse ...

Two Proteins in Young Blood Give Synapses a SPARC

RESEARCH NEWS 2019-06-11 Research News Human neurons sprouted more synapses and fired off more action potentials when bathed in serum from young, but not old, mice, according to a study published June 3 in Proceedings of the National Academy of Sciences. Kathlyn Gan and Thomas ...

Reproducible Brain Organoids Could Offer New Models for Research

RESEARCH NEWS 2019-06-06 Research News Brain organoids, those tiny balls of cells grown in a dish to model the human brain, are plagued by a major problem—they are each unique. That may be about to change. Scientists led by Paola Arlotta, Harvard University, Cambridge, ...

Mutant Tau Messes Up Connectivity of Newborn Neurons

RESEARCH NEWS 2019-06-05 Research News Few studies have examined what happens to adult-born neurons in frontotemporal dementia. In the May 27 Journal of Neuroscience, researchers led by María Llorens-Martín at the Universidad Autónoma de Madrid report that in a mouse model of the ...

The Mutation You Want: It Protects the Brain, Extends Life

RESEARCH NEWS 2019-05-31 Research News The lucky carriers of a coding variant in the phospholipase Cγ2 (PLCG2) gene may reap even more benefits than previously thought. In the May 27 Acta Neuropathologica, researchers confirm that people with the rs72824905-G allele not only ...

Anti-Tau Antibody Looks Safe, Hits Target

RESEARCH NEWS 2019-05-31 Research News As anti-tau antibodies move through clinical trials, Biogen researchers led by Tien Dam publish results from the Phase 1b trial of their antibody BIIB092 in the June Lancet Neurology. This antibody recognizes N-terminal fragments of tau, ...

Is APOB a Risk Gene for Early Onset Alzheimer’s?

RESEARCH NEWS 2019-05-30 Research News Known gene mutations explain but a fraction of early onset Alzheimer’s disease. A majority of people who become symptomatic before age 65 have neither an autosomal-dominant inheritance pattern nor mutation. So what is causing their dementia? ...

Microglia Instigate ‘Chemofog’ by Squelching Myelination

RESEARCH NEWS 2019-05-29 Research News We can now add myelination to the list of critical functions put on hold by cantankerous microglia. A paper published May 10 in Neuron reported that in mice treated with the widely used chemotherapy drug methotrexate, microglia became ...

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