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Flortaucipir Imaging Distinguishes Alzheimer’s From Other Disorders

RESEARCH NEWS 2018-09-21 Research News Most tau PET tracers detect only the type of misfolded tau found in Alzheimer’s disease. In the September 18 JAMA, researchers led by Rik Ossenkoppele at VU University Medical Center, Amsterdam, and Oskar Hansson at Lund University, Sweden, ...

In Conditional BACE1 Knockouts, Hippocampal Axons Compromised

RESEARCH NEWS 2018-09-21 Research News BACE1 knockout mice have more than their fair share of problems, but is it because they lack the enzyme during development or during adulthood? New conditional knockouts from the lab of Robert Vassar, Northwestern University, Chicago, ...

Does LRRK2 Sweep α-Synuclein from the Cell?

RESEARCH NEWS 2018-09-18 Research News Mutations in the LRRK2 gene spike the risk of Parkinson’s disease, but researchers still do not understand how. Two recent studies strengthen the idea that LRRK2 modulates the endolysosomal disposal system of the cell. In the September 12 ...

Cognitive Deficits Worse with ALS Stage

RESEARCH NEWS 2018-09-15 Research News When Stephen Hawking died after a 55-year battle with amyotrophic lateral sclerosis—his body paralyzed but his mind apparently intact—his celebrity helped spread a misconception that ALS spares the mind. Just how unusual Hawking was is ...

Does Cognition Change With the Seasons?

RESEARCH NEWS 2018-09-13 Research News For everything there is a season—perhaps even cognition? A September 4 paper in PLoS Medicine reports that people tested on neuropsychological tests in the summer and fall outperformed people tested in the winter and spring. The ebb and flow ...

Exercise Pill? Pharmacological Mimics Boost Cognition in Lazy Mice

RESEARCH NEWS 2018-09-09 Research News Exercise fends off some of the ills of aging, maybe even Alzheimer’s disease, but just how physical activity benefits the brain is unclear. In a new study in the September 7 Science, researchers led by Rudy Tanzi at Massachusetts General ...

ALS Mutations Stiffen Profilin, Steer Protein Toward Aggregation

RESEARCH NEWS 2018-09-08 Research News Several different mutations in the tiny profilin-1 are responsible for some familial forms of amyotrophic lateral sclerosis. According to computational models published in the August 30 Scientific Reports, these variants restrict the protein ...

Tau Stymies Transport Through Neuron’s Nucleus

RESEARCH NEWS 2018-09-07 Research News Phosphorylated tau interferes with the finely tuned process of nuclear transport, according to a paper in the September 5 Neuron. Scientists co-led by Bradley Hyman, Massachusetts General Hospital, Charlestown, and Jeffrey Rothstein, Johns ...

Flortaucipir Meets Primary Endpoints in Phase 3 Autopsy Trial

COMMUNITY NEWS 2018-09-07 Community News Eli Lilly announced Wednesday that its tau PET ligand, flortaucipir, aka AV1451, met co-primary endpoints in a small Phase 3 trial. This autopsy study apparently confirmed, postmortem, that flortaucipir had predicted tau pathology and ...

Does Retinal Thinning Reflect Early Alzheimer’s?

RESEARCH NEWS 2018-08-31 Research News A sophisticated eye scanner might detect early signs of Alzheimer’s disease, at least according to a paper in the August 23 JAMA Ophthalmology. Researchers led by Gregory van Stavern and Rajendra Apte, both at Washington University, St. ...

Let ’Er RIP: ALS/FTD Variant Plus Aging Unleash Deadly Kinase

RESEARCH NEWS 2018-08-31 Research News Living up to its ominous acronym, RIPK1, the receptor-interacting serine/threonine-protein kinase 1 unleashes powerful signaling cascades that can fell cells within hours. Thankfully, several inhibitors normally keep these deadly doings in ...

Conformers Confirmed: Structure of Pick’s Tau Distinct from AD Tau

RESEARCH NEWS 2018-08-31 Research News In recent years, support has grown for the idea that the same aggregating protein can fold up into different toxic shapes, giving rise to distinct neurodegenerative diseases. Now, in the August 29 Nature, researchers led by Michel Goedert ...

Tiny Passageways Connect Skull Bone Marrow to the Brain

RESEARCH NEWS 2018-08-30 Research News Scientists have discovered secret corridors that connect the bone marrow in the skull directly to the brain. According to a paper published August 27 in Nature Neuroscience, these tiny channels serve as an express route for marrow cells, ...

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