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Gene Disruption Haunts Tau Mouse—Knock-Ins Look Promising

RESEARCH NEWS 2019-07-16 Research News Two recent papers detail stumbles and strides for tau models. In the June 6 Nature Communications, scientists led by Michael Koob and Karen Ashe, University of Minnesota, Minneapolis, reported that most of the rampant neurodegeneration seen ...

Herpesvirus: Trigger for Many Brain Pathologies?

CONFERENCE COVERAGE 2019-07-14 Conference Coverage This is Part 2 of a two-part story. At a workshop during the 11th International Conference on HHV-6 and HHV-7, held June 23 to 26, 2019, in Quebec City, Canada, experts on human herpesviruses treated Alzheimer’s researchers to a lesson ...

In PD Model, α-Synuclein Spreads from Intestine to Brain

CONFERENCE COVERAGE 2019-07-12 Conference Coverage The hypothesis that Parkinson’s disease could arise within the belly, not the brain, now gains support with a new mouse model. Valina Dawson of Johns Hopkins University, Baltimore, reported at a joint symposium held June 16-21 in ...

Cognitive Decline Trips Up API Trials of BACE Inhibitor

RESEARCH NEWS 2019-07-12 Research News The Alzheimer’s field was dealt another body blow yesterday with the announcement of a premature end to testing of Novartis/Amgen’s BACE inhibitor CNP520, aka umibecestat, in two Phase 2/3 trials. Part of the Alzheimer’s Prevention ...

Going Viral: Alzheimer’s Research at Herpes Conference

CONFERENCE COVERAGE 2019-07-11 Conference Coverage This is Part 1 of a two-part story. In a rare meeting of two worlds, experts on human herpesviruses and Alzheimer’s disease shared the stage at a special workshop at the 11th International Conference on HHV-6 and HHV-7, held June 23 to ...

Deleting CD33 Benefits Mice—If Their Microglia Express TREM2

RESEARCH NEWS 2019-07-11 Research News From their perch on the microglial surface, CD33 and TREM2 exact opposing forces on microglial functions, including phagocytosis and inflammatory responses. Now, in a study published in Neuron on July 10, researchers led by Rudolph Tanzi at ...

Epilogue on Edonerpic: It Does Not Work in Alzheimer’s

RESEARCH NEWS 2019-07-10 Research News The drug edonerpic maleate failed to slow cognitive decline in Alzheimer’s patients, according to a paper published online July 8 in JAMA Neurology. Scientists led by Lon Schneider, University of Southern California, Los Angeles, reported ...

Invading T Cells Quash Neurogenesis

RESEARCH NEWS 2019-07-06 Research News Adult mammalian brains eke out limited numbers of new neurons in select regions, but over time, even that production dwindles. Why is unclear. New evidence from the lab of Anne Brunet, Stanford University, California, suggests invading ...

Settlement Reached Between UCSD and USC, Paul Aisen

COMMUNITY NEWS 2019-07-05 Community News A bitter dispute that pitted the University of California, San Diego, against the University of Southern California and Paul Aisen has been settled. USC will pay UCSD $50 million to compensate for its sudden recruitment of Aisen and other ...

Dopaminergic Neurons Conjured from Astrocytes Restore Motion

CONFERENCE COVERAGE 2019-07-05 Conference Coverage Astrocytes are devoted nurturers of neurons—facilitating synaptic transmission, maintaining the blood-brain barrier, and repairing injuries are but a few of their ministrations. As if that weren’t enough, scientists described an ...

Prostate Cancer Therapy Makes Dementia More Likely

RESEARCH NEWS 2019-07-03 Research News In the largest U.S. study to date on androgen-deprivation therapy and dementia, researchers led by Ravishankar Jayadevappa, University of Pennsylvania, Philadelphia, found that among older men with prostate cancer, those who received this ...

Down to Sex? Boy and Girl Microglia Respond Differently

CONFERENCE COVERAGE 2019-07-02 Conference Coverage Some microglia are from Mars; others from Venus. Well, no. But in some scenarios, to which sex a microglial cell belongs appears to hold some sway over how it responds. Consider tau. At a joint Keystone symposia—Neurodegenerative ...

TREM2, Microglia Dampen Dangerous Liaisons Between Aβ and Tau

CONFERENCE COVERAGE 2019-07-02 Conference Coverage That microglia play a central role in neurodegenerative disease has become a premise; it’s no longer a question. The questions are all about the how. This was abundantly clear at joint symposia held June 16–21 in Keystone, Colorado. At ...

Does Serotonin Pathology Foreshadow Parkinson’s Disease?

RESEARCH NEWS 2019-06-28 Research News Parkinson’s disease inflicts brain damage years before patients begin shaking, slowing down, and feeling stiff. What happens before motor symptoms surface, however, remains murky. In a study in the June 19 Lancet Neurology, researchers led ...

Gently Used: Can Recycled Microglia Receptors Prevent Plaque?

RESEARCH NEWS 2019-06-28 Research News Microglia do much of the heavy lifting when it comes to removing Aβ, but how do they do it? Researchers led by Douglas Green, St. Jude Children’s Research Hospital, Memphis, Tennessee, have identified an endocytic recycling process by which ...

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