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Background

Other This database is a repository of genetic variants in genes linked to Alzheimer’s disease (AD). Currently, it includes the three genes associated with autosomal-dominant AD (APP, PSEN1, PSEN2), plus two genes associated with AD by way of genetics or the ...

Glossary

Other Association A genetic association indicates a correlation between a phenotype and a DNA variant. Within this database, associations between a variant and disease are reported based on the study investigators’ criteria for statistical significance, ...

Methods

Other The Alzforum Mutations database aggregates information about genetic variants reported in the literature. This database focuses on a subset of genes implicated in Alzheimer’s disease. We started out by curating variants in genes associated with autosomal ...

FAQ

Other 1.  Is there a “burden of proof” for inclusion? All variants in included genes (currently APP, PSEN1, PSEN2, MAPT, TREM2) are eligible for inclusion, whether they were reported in a peer-reviewed publication, a meeting abstract, a review, or by personal ...

Background

Other As the pace of ascertaining genetic data accelerates and the volume of data grows, researchers face the challenge of understanding the impact of observed genetic variability. Is a given sequence variant neutral, protective, or pathogenic? Together with ...

FAQ

Other 1. How do I use this database? HEX is designed to provide genetic variability data on a phenotypically characterized set of individuals; specifically, people who have aged without neurodegeneration. For example, a researcher may want to consult HEX if (s ...

Glossary

Other 3' 3', pronounced 3 prime, refers to the third carbon of the sugar rings that form the DNA backbone. The 3' end is the end of the DNA that terminates at the hydroxyl group attached to the third carbon of the sugar ring. DNA sequences are ...

Methods

Other Sample Selection and Demographics HEX Version 1.0 includes DNA from 468 individuals categorized as cognitively and neuropathologically healthy. DNA was extracted from brain tissue obtained from several UK and US brain banks, including the Thomas Willis ...

Glen Campbell: I’ll Be Me

Other This documentary chronicles the “Goodbye Tour.” In this series of concerts performed in 2012, country musician Glen Campbell marked the end of his 60-year career after he was diagnosed with Alzheimer’s disease in 2011. With the concerts, Campbell said ...

Versioning History

Other AlzBiomarker version 1.0 was released December 2015 and meta-analysis results of the initial dataset have been published (Olsson et al., 2016).  Version 1.1 was released April 2016 adding neurogranin data and analyses. Version 1.2 was released June 2016 ...

Alzheimer's: Every Minute Counts

Other This PBS special paints a grim picture of the burden of Alzheimer’s disease in the United States. The documentary draws upon personal accounts of people with AD and their caregivers, as well as the opinions of researchers, doctors, economists, and ...

MacArthur Foundation 100Change Competition Citations

Other The 2016 report of Alzheimer’s Disease International, the global federation of 85 Alzheimer’s Associations, projects 135 million dementia cases by 2050; global cost is projected to rise from $818 billion in 2016 to $1 trillion by 2018.  Global aging ...

lumbar puncture tray

Other Protocols I understand there is now a manufacturer who will assemble the lumbar puncture tray with the correct polypropylene tubes for AB, tau and p-tau. Does anyone know the name of the manufacturer? many thanks. ...

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