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TBA42

RESEARCH MODELS Summary The TBA42 model was designed to produce and secrete an N-terminally truncated Aβ peptide. TBA42, which stands for truncated beta-amyloid 42, specifically encodes an Aβ 3–42 peptide with a glutamine substituted for the naturally occurring glutamate ...

PLB4 (hBACE1)

RESEARCH MODELS Summary This mouse model is useful for studying the biology of BACE1 and for investigating compounds that target β-secretase. The neuropathology and behavior of these mice indicate that even a subtle increase in human BACE1 expression, about twofold ...

AAV-AD

RESEARCH MODELS Summary Adeno-associated viral (AAV) vectors separately encoding human APP with the Swedish and London mutations and human PSEN1 with the M146L mutation were injected bilaterally into the hippocampi of young adult (8-week-old) rats. AAV-AD rats develop ...

Tau P301S (Line PS19)

RESEARCH MODELS Summary This widely used tauopathy model was developed at the University of Pennsylvania School of Medicine by Virginia Lee, John Trojanowski, and colleagues. As first reported in 2007 on a mixed background, PS19 mice develop neuronal loss and brain ...

Tg4-42

RESEARCH MODELS Summary The Tg4-42 model was engineered to produce the peptide Aβ 4-42, one of a variety of N-terminally truncated Aβ species identified in the AD brain. The Aβ 4-42 peptide, which begins with a phenylalanine at position 4, may be a particularly abundant ...

Tau (Alz50)

ANTIBODY monoclonal Alz50 laboratory Formerly available through Dr. Peter Davies. For updated information, contact antibodies@alzforum.org. Raised against human basal forebrain homogenate. Epitope subsequently determined to include amino acids 2-10 and 312-342 of ...

Bcl-2 (100)

ANTIBODY monoclonal 100 manufacturer cat# BMAS-949p   biotin 26kDa Bcl-2 Cell Death Accurate Flow Cytometry Human Bcl-2 http://alzforum.org/res/com/ant/default.asp?antibodyID=384 ...

Bcl-6 (P1F6)

ANTIBODY monoclonal P1F6 manufacturer cat# MED-CLA355   supernatant Bcl-6 Gene Product Cell Death Accurate Immunohistochemistry Human Bcl-6 http://alzforum.org/res/com/ant/default.asp?antibodyID=391 ...

Bcl-X

ANTIBODY monoclonal manufacturer cat#<br />AXL-3658     Cell Death Accurate Rabbit Bcl-X http://alzforum.org/res/com/ant/default.asp?antibodyID=393 ...

Bcl-XS

ANTIBODY monoclonal manufacturer cat# YSRT-<br />AHP541   pretreated   Cell Death Accurate Rabbit Immunohistochemistry Western Blot Bcl-XS http://alzforum.org/res/com/ant/default.asp?antibodyID=394 ...

Bcl-6 (PG-B6p)

ANTIBODY monoclonal PG-B6p manufacturer cat# AXL-7334M   pretreated   Cell Death Accurate Immunohistochemistry Immunoblotting Immunoprecipitation Human Bcl-6 http://alzforum.org/res/com/ant/default.asp?antibodyID=395 ...

Bcl-1 (DCS6)

ANTIBODY monoclonal DCS6 manufacturer cat# MED-CLA157   supernatant Cyclin D1 (PRAD-1 or bcl-1) Cell Death Accurate Immunohistochemistry Human Monkey Mouse Rat Bcl-1 http://alzforum.org/res/com/ant/default.asp?antibodyID=396 ...

Bcl-2 (100)

ANTIBODY monoclonal 100 manufacturer cat# BYA-9535-1 ascites not-mouse Cell Death Accurate Immunohistochemistry Human Bcl-2 http://alzforum.org/res/com/ant/default.asp?antibodyID=383 ...

Bcl-2 (100)

ANTIBODY monoclonal 100 manufacturer cat# FMAS-949p FITC Cell Death Accurate Flow Cytometry Human Bcl-2 http://alzforum.org/res/com/ant/default.asp?antibodyID=385 ...

Bcl-2 (100)

ANTIBODY monoclonal 100 manufacturer cat# MAS-949p purified Cell Death Accurate Flow Cytometry Human Bcl-2 http://alzforum.org/res/com/ant/default.asp?antibodyID=386 ...

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