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Atg16LΔWD

RESEARCH MODELS Summary In addition to their roles in canonical autophagy, some protein components of the autophagy machinery are involved in recycling cell-surface receptors in microglia (see Jun 2019 News). Atg16L ΔWD mice express a prematurely truncated version of the ...

Plcγ2-P522R knock-in

RESEARCH MODELS Summary The PLCG2 gene encodes the enzyme phospholipase C gamma 2 (PLCγ2), a mediator of transmembrane signaling in microglia that acts downstream of TREM2. A rare variant in this gene, P522R, has been associated with reduced risks of Alzheimer’s disease ...

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