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AppSAA Knock-in

RESEARCH MODELS Summary The App SAA mouse joins a list of knock-in models that carry a humanized Aβ sequence within the murine App gene (App knock-in (humanized Aβ), APP NL-F Knock-in, APP NL-G-F Knock-in). As in the latter two models, the App gene was further modified ...

PA-Rab5

RESEARCH MODELS Summary Rab5 is a small GTPase that regulates endosome trafficking, sorting, and fusion. Enlarged Rab5-positive endosomes are among the earliest neuropathological signs of Alzheimer’s disease and Down’s syndrome (Cataldo et al., 2000), and a body of ...

Atg16LΔWD

RESEARCH MODELS Summary In addition to their roles in canonical autophagy, some protein components of the autophagy machinery are involved in recycling cell-surface receptors in microglia (see Jun 2019 News). Atg16L ΔWD mice express a prematurely truncated version of the ...

Plcγ2-P522R knock-in

RESEARCH MODELS Summary The PLCG2 gene encodes the enzyme phospholipase C gamma 2 (PLCγ2), a mediator of transmembrane signaling in microglia that acts downstream of TREM2. A rare variant in this gene, P522R, has been associated with reduced risks of Alzheimer’s disease ...

App knock-in (humanized Aβ)

RESEARCH MODELS Summary App hu/hu mice carry a humanized Aβ sequence within the murine App gene. In this knock-in model, created using CRISPR/Cas9 technology, expression of App is driven by its natural promoter and is expected to show normal cell-type and temporal ...

App knock-in (humanized Aβ) (Leuven)

RESEARCH MODELS Summary App hu/hu rats carry a humanized Aβ sequence within the rat App gene. In this knock-in model, created using CRISPR/Cas9 technology, expression of App is driven by its natural promoter and is expected to show normal cell-type and temporal ...

App knock-in (humanized Aβ) (Leuven); Psen1 knock-in (M139T)

RESEARCH MODELS Summary App hu/hu;Psen1M139T +/+ rats carry a humanized Aβ sequence within the rat App gene and the AD-linked M139T mutation in the rat Psen1 gene. These knock-in animals are homozygous for both humanized App and Psen1 M139T. Levels of APP and its ...

PS19 with humanized TREM2 (R47H)

RESEARCH MODELS Summary People who carry one copy of the R47H variant of TREM2 have an approximately threefold greater risk of developing Alzheimer’s disease than do people homozygous for the common variant. Earlier mouse models were generated to explore the effects of ...

PS19 with humanized TREM2 (common variant)

RESEARCH MODELS Summary These mice, referred to here as PS19-TREM2 CV, carry transgenes encoding the common variant of human TREM2 and human MAPT with the P301S mutation linked to frontotemporal dementia, on a mouse-Trem2-null background. This model was generated by ...

TREM2, humanized (R47H)

RESEARCH MODELS Summary People who carry one copy of the R47H variant of TREM2 have an approximately threefold greater risk of developing Alzheimer’s disease than do people homozygous for the common variant. This mouse model, referred to here as TREM2 R47H, expresses the ...

TREM2, humanized (common variant)

RESEARCH MODELS Summary This mouse model, referred to here as TREM2 CV, expresses the common variant of human TREM2 in the absence of mouse Trem2. Transgenic TREM2 is expressed in microglia and macrophages, where it was shown to function properly in an ex vivo assay. ...

Psen1 L435F knock-in

RESEARCH MODELS Summary The L435F mutation in PSEN1 was found in affected individuals in a family with early onset AD (Heilig et al., 2010). This knock-in rat model carries the homologous mutation in the rat Psen1 gene and a humanized Aβ sequence within the rat App gene ...

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