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Bace1 conditional knockout (Tesco)

RESEARCH MODELS Summary This is the second of two similar models designed to mimic BACE1 inhibition, in which researchers can control the timing of BACE1 deficiency. These conditional knockouts avoid the developmental effects of BACE1 deficiency that are seen in germline ...

MAPT G389_I392del

MUTATIONS MAPT 44101377 GRCh37 (105) GGGCGGAGATCG- Exon 13 Deletion Coding Unknown. Severe atrophy of the frontal and temporal lobes, hippocampus, and amygdala. Neurofibrillary tangles, neuropil threads, Pick bodies, and astrocytic inclusions, composed of 3R-tau. ...

MAPT D252V

MUTATIONS MAPT 44073963 GRCh37 (105) A T Exon 9 Point, Missense Coding Unknown. Widespread atrophy, particularly severe in the temporal and frontal lobes, the caudate nucleus, the hippocampus, and the amygdala. Neurofibrillary tangles, pretangles, neuropil threads, ...

SHRSP/FAD

RESEARCH MODELS Summary Pure Alzheimer’s disease—in which brains contain only the pathological hallmarks of AD, amyloid plaques and neurofibrillary tangles—is rare: In one recent study of nearly 900 autopsy samples with AD pathology, approximately 85 percent also ...

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  • TYPE: Alzpedia x
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  • TYPE: Biomarker Meta Analysis x
  • TYPE: Therapeutics x
  • Date Range : Nov 2019 to Feb 2020 x

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