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SHRSP/FAD

RESEARCH MODELS Summary Pure Alzheimer’s disease—in which brains contain only the pathological hallmarks of AD, amyloid plaques and neurofibrillary tangles—is rare: In one recent study of nearly 900 autopsy samples with AD pathology, approximately 85 percent also ...

APOE4 Knock-In, floxed (CureAlz)

RESEARCH MODELS Summary This knock-in mouse belongs to a set of models designed to allow investigators to compare the effects of the various human APOE isoforms and to conditionally disrupt APOE expression. In this version, “E4F,” the coding region of the mouse Apoe gene ...

APOE3 Knock-In, floxed (CureAlz)

RESEARCH MODELS Summary This knock-in mouse belongs to a set of models designed to allow investigators to compare the effects of the various human APOE isoforms and to conditionally disrupt APOE expression. In this version, “E3F,” the coding region of the mouse Apoe gene ...

APOE2 Knock-In, floxed (CureAlz)

RESEARCH MODELS Summary This knock-in mouse belongs to a set of models designed to allow investigators to compare the effects of the various human APOE isoforms and to conditionally disrupt APOE expression. In this version, “E2F,” the coding region of the mouse Apoe gene ...

Thy1-αSyn “Line 61” Mouse

RESEARCH MODELS Summary The Thy1-αSyn mouse model, a.k.a. Line 61, overexpresses human α-synuclein under the Thy1 promoter (Rockenstein et al., 2002). It is one of the most extensively characterized animal models of Parkinson’s disease (PD), and reproduces several ...

PWK.APP/PS1

RESEARCH MODELS Summary In an effort to mimic the genetic diversity seen in human populations, scientists have crossed popular transgenic mouse models of Alzheimer’s disease with mice of various genetic backgrounds (see 28 Dec 2018 news; 21 Jun 2019 news).  PWK.APP/PS1 ...

WSB.APP/PS1

RESEARCH MODELS Summary In an effort to mimic the genetic diversity seen in human populations, scientists have crossed popular transgenic mouse models of Alzheimer’s disease with mice of various genetic backgrounds (see 28 Dec 2018 news; 21 Jun 2019 news). WSB.APP/PS1 ...

CAST.APP/PS1

RESEARCH MODELS Summary In an effort to mimic the genetic diversity seen in human populations, scientists have crossed popular transgenic mouse models of Alzheimer’s disease with mice of various genetic backgrounds (see 28 Dec 2018 news; 21 Jun 2019 news).  CAST.APP/PS1 ...

APPswe/PSEN1dE9 (C57BL6)

RESEARCH MODELS Summary APPswe/PSEN1dE9 mice carry two transgenes with AD-linked mutations: a chimeric mouse/human APP with the Swedish mutation and human PSEN1 lacking exon 9 (dE9), both under the control of the mouse prion protein promoter. This popular model was ...

AD-BXD

RESEARCH MODELS “AD-BXD” refers to a panel of transgenic mouse strains, created to model the genetic diversity seen in human populations. These mice represent a unique resource for scientists seeking to identify genetic factors that influence resilience or vulnerability ...

AppNL-G-F/MAPT double knock-in

RESEARCH MODELS Summary App NL-G-F /MAPT double knock-in mice represent a unique model for studying the nexus between human Aβ and human tau. These mice were created by crossing App NL-G-F mice with MAPT knock-in mice. In the former line, the endogenous mouse App gene ...

MAPT knock-in

RESEARCH MODELS Summary It has been suggested that differences in mouse and human tau may partially underlie the difficulty in modeling Alzheimer’s disease in mice (see Alzforum webinar). In this knock-in model, the entire genomic sequence of murine Mapt from exon 1 to ...

LRRK2 G2019S KI Mouse

RESEARCH MODELS This constitutive knock-in mouse model was generated by introducing the LRRK2 G2019S point mutation into exon 41 of the mouse LRRK2 gene (Matikainen-Ankney et al., 2016). Homozygous mutant mice appear grossly normal. They generate litters comparable in ...

CamKII;(GR)80

RESEARCH MODELS A G 4 C 2 hexanucleotide repeat expansion in chromosome 9 open reading frame 72 (C9ORF72) is the most frequent genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). This repeat expansion encodes five dipeptide repeat ...

C9ORF72(AAV)(G4C2)149

RESEARCH MODELS A (G 4 C 2) hexanucleotide repeat expansion in chromosome 9 open reading frame 72 (C9ORF72) is the most frequent genetic cause of frontotemporal dementia and amyotrophic lateral sclerosis. Bidirectional transcription of this expansion yields sense (G 4 C ...

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