SEARCH RESULTS

29568 RESULTS

Sort By:

5xFAD (C57BL6)

RESEARCH MODELS Summary 5xFAD mice express human APP and PSEN1 transgenes with a total of five AD-linked mutations: the Swedish (K670N/M671L), Florida (I716V), and London (V717I) mutations in APP, and the M146L and L286V mutations in PSEN1. 5xFAD mice were originally ...

Bace1 conditional knock-out (neonatal, forebrain) (Vassar)

RESEARCH MODELS Summary In these conditional knock-out mice, Bace1 expression is eliminated in forebrain excitatory neurons beginning during the first postnatal week. These mice were generated by crossing mice with a floxed Bace1 gene to mice carrying a transgene ...

Bace1 conditional knock-out (adult, whole body) (Vassar)

RESEARCH MODELS Summary These transgenic mice were designed to mimic BACE1 inhibition, while avoiding the developmental effects of Bace1 deficiency that are seen in germline knock-outs. They were generated by crossing mice with a floxed Bace1 gene to mice carrying a ...

AAV-AD

RESEARCH MODELS Summary Adeno-associated viral (AAV) vectors separately encoding human APP with the Swedish and London mutations and human PSEN1 with the M146L mutation were injected bilaterally into the hippocampi of young adult (8-week-old) rats. AAV-AD rats develop ...

BACE1 conditional knock-out (Hu, Yan)

RESEARCH MODELS Summary These transgenic mice were designed to mimic BACE1 inhibition, while avoiding the developmental effects of Bace1 deficiency that are seen in germline knock-outs. They were generated by crossing mice with a floxed Bace1 gene (Bace1 fl/fl) to mice ...

BACE1 cKO (Hu, Yan) X 5xFAD

RESEARCH MODELS Summary These transgenic mice were designed to mimic BACE1 inhibition in the context of amyloid pathology, while avoiding the developmental effects of Bace1 deficiency that are seen in germline knockouts. Mice are hemizygous for human APP and PSEN1 ...

Snx1*D465N/APOE4/Trem2*R47H

RESEARCH MODELS Summary The epsilon-4 allele of Apolipoprotein E and the R47H variant of TREM2  have each been found to confer an approximately threefold increased risk for Alzheimer’s disease in humans heterozygous for either allele. The SNX1 (sorting nexin 1) gene ...

Kif21b*T82T/APOE4/Trem2*R47H

RESEARCH MODELS Summary The epsilon-4 allele of Apolipoprotein E and the R47H variant of TREM2  have each been found to confer an approximately threefold increased risk for Alzheimer’s disease in humans heterozygous for either allele. The motor protein KIF21B (Kinesin ...

Clasp2*L163P/APOE4/Trem2*R47H

RESEARCH MODELS Summary The epsilon-4 allele of Apolipoprotein E and the R47H variant of TREM2  have each been found to confer an approximately threefold increased risk for Alzheimer’s disease in humans heterozygous for either allele. CLASP2 (CLIP-associating protein 2) ...

Sorl1*A528T/APOE4/Trem2*R47H

RESEARCH MODELS Summary The epsilon-4 allele of Apolipoprotein E and the R47H variant of TREM2  have each been found to confer an approximately threefold increased risk for Alzheimer’s disease in humans heterozygous for either allele. A528T is a common variant of SORL1 ...

hCR1 KI on APOE4/Trem2

RESEARCH MODELS Summary The epsilon-4 allele of Apolipoprotein E and the R47H variant of TREM2  have each been found to confer an approximately threefold increased risk for Alzheimer’s disease in humans heterozygous for either allele. Variations in complement receptor 1 ...

Mthfr*C677T/APOE4/Trem2*R47H

RESEARCH MODELS Summary The epsilon-4 allele of Apoliporotein E and the R47H variant of TREM2  have each been found to confer an approximately threefold increased risk for Alzheimer’s disease in humans heterozygous for either allele. The C677T variant of MTHFR ...

TDP-43 (Wt-TAR6/6)

RESEARCH MODELS Summary This mouse model of ALS expresses wild-type human TDP-43 in postnatal neurons. Mice homozygous for the human TARDP transgene are referred to as TAR6/6, while mice hemizygous for the transgene are called TAR6. This description refers to homozygous, ...

AAV-GFP–(GR)100

RESEARCH MODELS Summary The six-nucleotide (GGGGCC) repeat expansion in C9ORF72 encodes five dipeptide repeat proteins that accumulate in ALS/FTD: glycine-arginine (GR), proline-arginine (PR), glycine-alanine (GA), proline-alanine (PA), and glycine-proline (GP). The GFP– ...

AAV-GFP-(GA)50

RESEARCH MODELS Summary The six-nucleotide (GGGGCC) repeat expansion in C9ORF72 encodes five dipeptide-repeat proteins that accumulate in ALS/FTD: glycine-arginine (GR), proline-arginine (PR), glycine-alanine (GA), proline-alanine (PA), and glycine-proline (GP). The GFP- ...

Current Filters

  • TYPE: Antibody x
  • TYPE: Research Models x

Remove all filters

Filter By

DATE RANGE
  • All
  • Past 7 Days
  • Past 30 Days
  • Past 90 Days
  • Past 12 Months
  • Specific Dates
    1. From
      To

TYPE
DATABASE