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AppNL-G-F/MAPT double knock-in

RESEARCH MODELS Summary App NL-G-F /MAPT double knock-in mice represent a unique model for studying the nexus between human Aβ and human tau. These mice were created by crossing App NL-G-F mice with MAPT knock-in mice. In the former line, the endogenous mouse App gene ...

MAPT knock-in

RESEARCH MODELS Summary It has been suggested that differences in mouse and human tau may partially underlie the difficulty in modeling Alzheimer’s disease in mice (see Alzforum webinar). In this knock-in model, the entire genomic sequence of murine Mapt from exon 1 to ...

LRRK2 G2019S KI Mouse

RESEARCH MODELS This constitutive knock-in mouse model was generated by introducing the LRRK2 G2019S point mutation into exon 41 of the mouse LRRK2 gene (Matikainen-Ankney et al., 2016). Homozygous mutant mice appear grossly normal. They generate litters comparable in ...

CamKII;(GR)80

RESEARCH MODELS A G 4 C 2 hexanucleotide repeat expansion in chromosome 9 open reading frame 72 (C9ORF72) is the most frequent genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). This repeat expansion encodes five dipeptide repeat ...

C9ORF72(AAV)(G4C2)149

RESEARCH MODELS A (G 4 C 2) hexanucleotide repeat expansion in chromosome 9 open reading frame 72 (C9ORF72) is the most frequent genetic cause of frontotemporal dementia and amyotrophic lateral sclerosis. Bidirectional transcription of this expansion yields sense (G 4 C ...

SHR24

RESEARCH MODELS Summary Following observations that monoclonal antibodies selective for truncated tau species recognize tau extracted from AD brains (Vechterova et al., 2003) and tau in the core of paired helical filaments (Novak et al., 1993; Skrabana et al., 2004), ...

SHR72

RESEARCH MODELS Summary Following observations that monoclonal antibodies selective for truncated tau species recognize tau extracted from AD brains (Vechterova et al., 2003) and tau in the core of paired helical filaments (Novak et al., 1993; Skrabana et al., 2004), ...

SHR318

RESEARCH MODELS Summary Following observations that monoclonal antibodies selective for truncated tau species recognize tau extracted from AD brains (Vechterova et al., 2003) and tau in the core of paired helical filaments (Novak et al., 1993; Skrabana et al., 2004), ...

TauP301L-AAV

RESEARCH MODELS Summary To create this model, an adeno-associated viral (AAV) vector encoding human tau with the P301L mutation was injected into the ventricles of neonatal mice. At 6 months of age, Tau P301L-AAV mice exhibit neurofibrillary tangles, gliosis, and ...

TauA152T-AAV

RESEARCH MODELS Summary The A152T variant of MAPT acts as a risk modifier that increases susceptibility to several neurodegenerative conditions, including Alzheimer's disease, frontotemporal dementia, and dementia with Lewy bodies. Tau 152T-AAV mice were created to ...

5xFAD (C57BL6)

RESEARCH MODELS Summary 5xFAD mice express human APP and PSEN1 transgenes with a total of five AD-linked mutations: the Swedish (K670N/M671L), Florida (I716V), and London (V717I) mutations in APP, and the M146L and L286V mutations in PSEN1. 5xFAD mice were originally ...

Bace1 conditional knock-out (neonatal, forebrain) (Vassar)

RESEARCH MODELS Summary In these conditional knock-out mice, Bace1 expression is eliminated in forebrain excitatory neurons beginning during the first postnatal week. These mice were generated by crossing mice with a floxed Bace1 gene to mice carrying a transgene ...

Bace1 conditional knock-out (adult, whole body) (Vassar)

RESEARCH MODELS Summary These transgenic mice were designed to mimic BACE1 inhibition, while avoiding the developmental effects of Bace1 deficiency that are seen in germline knock-outs. They were generated by crossing mice with a floxed Bace1 gene to mice carrying a ...

AAV-AD

RESEARCH MODELS Summary Adeno-associated viral (AAV) vectors separately encoding human APP with the Swedish and London mutations and human PSEN1 with the M146L mutation were injected bilaterally into the hippocampi of young adult (8-week-old) rats. AAV-AD rats develop ...

BACE1 conditional knock-out (Hu, Yan)

RESEARCH MODELS Summary These transgenic mice were designed to mimic BACE1 inhibition, while avoiding the developmental effects of Bace1 deficiency that are seen in germline knock-outs. They were generated by crossing mice with a floxed Bace1 gene (Bace1 fl/fl) to mice ...

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