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TDP-43 (Wt-TAR6/6)

RESEARCH MODELS Summary This mouse model of ALS expresses wild-type human TDP-43 in postnatal neurons. Mice homozygous for the human TARDP transgene are referred to as TAR6/6, while mice hemizygous for the transgene are called TAR6. This description refers to homozygous, ...

AAV-GFP–(GR)100

RESEARCH MODELS Summary The six-nucleotide (GGGGCC) repeat expansion in C9ORF72 encodes five dipeptide repeat proteins that accumulate in ALS/FTD: glycine-arginine (GR), proline-arginine (PR), glycine-alanine (GA), proline-alanine (PA), and glycine-proline (GP). The GFP– ...

AAV-GFP-(GA)50

RESEARCH MODELS Summary The six-nucleotide (GGGGCC) repeat expansion in C9ORF72 encodes five dipeptide-repeat proteins that accumulate in ALS/FTD: glycine-arginine (GR), proline-arginine (PR), glycine-alanine (GA), proline-alanine (PA), and glycine-proline (GP). The GFP- ...

Trem2 R47H KI (Haass)

RESEARCH MODELS R47H is a rare variant in TREM2 that triples the risk of Alzheimer’s disease in heterozygous carriers. To create a mouse model carrying a single copy of R47H Trem2 under the control of its natural regulatory elements, CRISPR/Cas9 was used to introduce the ...

APP+PS1

RESEARCH MODELS Summary APP+PS1 transgenic rats express human APP with the Swedish and Indiana mutations and human PSEN1 with the L166P mutation. Both transgenes are driven by the ubiquitin-C promoter. These rats exhibit amyloid pathology, neurodegeneration, and ...

APP21

RESEARCH MODELS Summary APP21 rats express human APP 695 containing the Swedish and Indiana mutations, driven by the ubiquitin-C promoter (Agca et al., 2008). Although these rats do not spontaneously develop amyloid pathology, they can serve as hosts for exogenously ...

TgF344-AD

RESEARCH MODELS Summary TgF344-AD rats express human APP with the Swedish mutation and human PSEN1 with the Δ exon 9 mutation. Both transgenes are driven by the mouse prion promoter (Cohen et al., 2013). Compared with levels of the endogenous rat proteins, TgF344-AD rats ...

McGill-R-Thy1-APP

RESEARCH MODELS Summary The McGill-R-Thy1-APP transgenic rat expresses human APP 751 with the Swedish and Indiana mutations, under the control of the murine Thy1.2 promoter. These rats are among the most extensively studied of the existing APP transgenic rat lines. ...

Tardp_RRM2mut

RESEARCH MODELS Summary RRM2mut mice harbor the p.F210I mutation within RNA recognition motif 2 (RRM2) of the endogenous mouse Tardp gene.  This line was generated after screening DNA archives from two large-scale chemical mutagenesis projects (Acevedo-Arozena et al., ...

Tardp LCDmut

RESEARCH MODELS Summary LCDmut mice harbor the p.M323K mutation within the C-terminal low complexity domain (LCD) of the endogenous mouse Tardp gene. This line was generated after screening DNA archives from two large-scale chemical mutagenesis projects (Acevedo-Arozena ...

Tardbp Q331K Knock-In

RESEARCH MODELS Summary CRISPR/Cas9 was used to introduce the p.Q331K mutation into the mouse Tardp gene (Fratta et al., 2018). These mice can be used to study the effects of the p.Q331K mutation when TDP-43 is expressed at physiological levels, under the control of its ...

Trem2 R47H KI (Lamb/Landreth) X APPPS1-21

RESEARCH MODELS Summary R47H is a rare variant in TREM2 that triples the risk of Alzheimer’s disease in heterozygous carriers of this variant. In order to study the effects of R47H TREM2 in the context of amyloidosis, Trem2 +/R47H mice were crossed with APPPS1-21 mice ...

Trem2 R47H KI (Lamb/Landreth)

RESEARCH MODELS Summary R47H is a rare variant in TREM2 that triples the risk of Alzheimer’s disease in heterozygous carriers. To create a mouse model carrying a single copy of R47H Trem2 under the control of its natural regulatory elements, CRISPR/Cas9 was used to ...

Ceacam1 KO/APOE4/Trem2*R47H

RESEARCH MODELS Summary The epsilon-4 allele of Apoliporotein E (APOE4) and the R47H variant of TREM2 have each been found to confer an approximately threefold increased risk for Alzheimer’s disease in humans heterozygous for either allele. Ceacam1 (Carcinoembryonic ...

Abca7 KO/APOE4/Trem2*R47H

RESEARCH MODELS Summary The epsilon-4 allele of Apoliporotein E (APOE4) and the R47H variant of TREM2 have each been found to confer an approximately threefold increased risk for Alzheimer’s disease in humans heterozygous for either allele. Variants in ABCA7, a member of ...

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