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Ceacam1 KO/APOE4/Trem2*R47H

RESEARCH MODELS Summary The epsilon-4 allele of Apoliporotein E (APOE4) and the R47H variant of TREM2 have each been found to confer an approximately threefold increased risk for Alzheimer’s disease in humans heterozygous for either allele. Ceacam1 (Carcinoembryonic ...

Abca7 KO/APOE4/Trem2*R47H

RESEARCH MODELS Summary The epsilon-4 allele of Apoliporotein E (APOE4) and the R47H variant of TREM2 have each been found to confer an approximately threefold increased risk for Alzheimer’s disease in humans heterozygous for either allele. Variants in ABCA7, a member of ...

Abca7*A1527G/APOE4/Trem2*R47H

RESEARCH MODELS Summary The epsilon-4 allele of Apoliporotein E (APOE4) and the rare R47H variant of TREM2 have each been found to confer an approximately threefold increased risk for Alzheimer’s disease in humans heterozygous for either allele. The p.A1527G allele of ...

App KO/APOE4/Trem2*R47H

RESEARCH MODELS Summary The epsilon-4 allele of Apoliporotein E (APOE4) and the R47H variant of TREM2 have each been found to confer an approximately threefold increased risk for Alzheimer’s disease in humans heterozygous for either allele.  This triple mutant line ...

hAbeta-loxP-KI

RESEARCH MODELS Summary These mice express APP with a “humanized” Aβ sequence. Three point mutations were introduced into exon 14 (exon numbering according to APP 695, with 16 exons) of the mouse App gene, to produce three amino acid substitutions within the Aβ sequence ...

Plcg2*M28L/APOE4/Trem2*R47H

RESEARCH MODELS Summary The epsilon-4 allele of Apoliporotein E (APOE4) and the R47H variant of TREM2 have each been found to confer an approximately threefold increased risk for Alzheimer’s disease in humans heterozygous for either allele. Plcg2 (phospholipase C, gamma ...

hAPP/APOE4/Trem2*R47H

RESEARCH MODELS Summary The epsilon-4 allele of Apoliporotein E (APOE4) and the R47H variant of TREM2 have each been found to confer an approximately threefold increased risk for Alzheimer’s disease in humans heterozygous for either allele. This triple mutant line ...

Il1rap KO/APOE4/Trem2*R47H

RESEARCH MODELS Summary The epsilon-4 allele of Apoliporotein E (APOE4) and the R47H variant of TREM2 have each been found to confer an approximately threefold increased risk for Alzheimer’s disease in humans heterozygous for either allele.  Il1rap (interleukin 1 ...

Plcg2 KO

RESEARCH MODELS Summary Plcg2 (phospholipase C, gamma 2) is highly expressed in microglia, and a rare coding variant, rs72824905 (p.P522R), has been found to decrease AD risk by almost one-third (Sims, et al., 2017). Another rare variant, rs61749044 (p.M28L), was found ...

APOE2 KI (JAX)

RESEARCH MODELS Summary APOE2 KI mice express humanized APOE (isoform 2) from the endogenous Apoe locus. Modification Details APOE2 KI mice were generated by using CRISPR/Cas9 to introduce two point mutations (leading to arginine to cysteine substitutions at amino acids ...

TREM2-BAC

RESEARCH MODELS Summary Loss-of-function mutations in TREM2 cause Nasu-Hakola disease (Paloneva et al., 2002), a rare, autosomal-recessive disorder characterized by bone fractures and early onset frontotemporal dementia (Paloneva et al., 2015), and may confer increased ...

TREM2-BAC X 5xFAD

RESEARCH MODELS Summary Loss-of-function mutations in TREM2 cause Nasu-Hakola disease (Paloneva et al., 2002), a rare, autosomal-recessive disorder characterized by bone fractures and early onset frontotemporal dementia (Paloneva et al., 2015), and may confer increased ...

TDP-43 (Q331K) Knock-In (Line 52)

RESEARCH MODELS Summary TDP-43 pathology characterizes a neurodegenerative disease spectrum that encompasses ALS and FTD. Transgenic mice have been used to study the pathological effects of mutant TDP-43, but the interpretation of their phenotypes is complicated by ...

TREM2, humanized (common variant) X 5XFAD

RESEARCH MODELS Summary Humanized TREM2 mice were created in a two-step process: First, researchers generated transgenic mice that carry BACs containing the common variant of human TREM2, including its regulatory elements. Then these BAC transgenic mice were back-crossed ...

TREM2, humanized (R47H) X 5XFAD

RESEARCH MODELS Summary The R47H variant of TREM2 has been found to confer an approximately threefold greater risk for Alzheimer’s disease in humans heterozygous for this allele. To study the effects of the R47H variant in the context of amyloidosis, mice carrying a ...

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