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Rudy Tanzi on Sixth Int. Conference on AD: Genetics I

COMMENT As a quick comment regarding Luc Buee's summary of Dr. Lindsay Farrer's talk on the genetics of AD and chromosome 12 in the Genetics I session of the Sixth Int. Conference on AD in Amsterdam, Dr. Buee reports that Dr. Farrer's genetic linka

Larry Sparks on Vitamin E: More Than an Antioxidant?

COMMENT Inflammation, free radicals, and cytokines are involved in a vascular cascade producing the transformation of macrophages into foam cells between the endothelial cell layer and the basement membrane of a blood vessel leading to formation of an atheroscler

Allen Roses on The A2M Deletion, Revisited

COMMENT Response from Allen Roses et al. to Tanzi Comment Below please find a short, absolute rebuttal to the comments made by Rudy Tanzi. It is followed by a fairly detailed commentary on each point, including copies of relevant dated correspondence that clarify

Rudy Tanzi on The A2M Deletion, Revisited

COMMENT Thanks for summarizing the three new A2M genetics papers and our reply in Nature Genetics (May 1999) in your "News" section this month. I wanted to share my thoughts on the controversy regarding the candidacy of A2M as a genetic risk factor for

Rudy Tanzi on The A2M Deletion, Revisited

COMMENT Response from Rudy Tanzi In Peter Hyslop's reply to the Alzheimer Forum News article on "A2M Revisited," he states: "The Rogaeva et al paper used the SAME family based association statistical methods as Blacker et al (ie the SDT and s-

Peter St. George-Hyslop on The A2M Deletion, Revisited

COMMENT The final sentences of the Alzheimer Research Forum News Summary leaves the impression that the cause of the disparity is due to differences in the statistical methods used. In fact, this is not at all correct. The Rogaeva et al paper used the SAME family

David Teplow on Toxic Protofibrillar Aβ

COMMENT In the news article cited above, two important facts need clarification. First, protofibrils are fibrillar. Second, the first demonstration that protofibrils were neurotoxic was published by my group, in collaboration with Drs. Hartley, Selkoe, and others

Brian Balin on Chlamydia Update

COMMENT This letter is in response to the recent article in Journal of Clinical Microbiology (38[2]:881-882, 2000) entitled "Failure to detect Chlamydia pneumoniae in brain sections of Alzheimer's Disease Patients" by Gieffers et al. Since we were

William Klein on Normal Prion Protein Signals with Fyn

COMMENT Coupling of cellular prion proteins to Fyn is a real surprise, but maybe it shouldn't be. Fyn keeps popping up. Shirazi and Wood showed that tangle-bearing neurons in AD have a hefty overload of Fyn. Gloria Lee showed Fyn and tau co-localize. Gail Jo

Lorenzo Refolo on Statins Reveal Role in Immune Response

COMMENT [I would like to note] that back in [August] 2000, we published a paper in Neurobiology of Disease (Refolo et al., 2000) demonstrating for the first time that cholesterol metabolism accelerates β-amyloid accumulation in a transgenic mouse model of AD. We

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