COMMENT This is an extremely exciting study that extends our understanding of the role of the human “virome” to neuropathology. The presence of viruses in human brains has long been recognized, but viral detection has been challenging and measurements of serum ...
COMMENT My concern about this work is that I find it difficult to square with the occurrence of Alzheimer’s disease in all Down's syndrome and in all carriers of some APP and PSEN mutations. The authors in their introduction bring up the idea of “slow virus” ...
COMMENT This is an interesting paper comparing postmortem brains of individuals with either AD neuropathology but no cognitive change (“preclinical AD”) or clinical AD, to brains of normal individuals. Subjects with clinical AD had higher levels of human ...
COMMENT This work by Readhead and colleagues is an important contribution to the field. The authors have performed a really impressive, in-depth analysis of postmortem Alzheimer’s disease brain tissue samples using modern bioinformatics techniques, and found ...
COMMENT Microbes and Alzheimer's Disease: Paradigm Change In this article Readhead et al. provide fresh impetus to the link between infection and Alzheimer’s disease (AD). A causal link has long been suspected (Itzhaki et al., 2016), underlined by the ...
University of EdinburghEdinburgh, United Kingdom
PAPER Rathore N, Ramani SR, Pantua H, Payandeh J, Bhangale T, Wuster A, Kapoor M, Sun Y, Kapadia S, Gonzalez L, Zarrin AA, Goate A, Hansen D, Behrens TW, Graham RR
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Detection frequency of human herpesviruses-6A,-6B, and-7 genomic sequences in central nervous system DNA samples from post-mortem individuals with unspecified encephalopathy.J Neurovirol. 2016 Aug;22(4):488-97. Epub 2016 Jan 4 PubMed: 26727906
PAPER Stowe RP, Peek MK, Cutchin MP, Goodwin JS22997083
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PAPER Eimer WA, et al
PAPER Pietiläinen-Nicklén J, Virtanen JO, Uotila L, Salonen O, Färkkilä M, Koskiniemi M25088617
PAPER Tanaka-Taya K, Kondo T, Mukai T, Miyoshi H, Yamamoto Y, Okada S, Yamanishi K
Seroepidemiological study of human herpesvirus-6 and-7 in children of different ages and detection of these two viruses in throat swabs by polymerase chain reaction.J Med Virol. 1996 Jan;48(1):88-94. PubMed: 8825716
PAPER Leibovitch EC, Jacobson S25462444
University of RochesterRochester
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