RESEARCH NEWS 2018-12-14 Research News For a PET ligand, validation is literally a matter of life and death. Its reliability rides on a direct comparison of tracer uptake in a living person with his or her autopsy result. In the December 3 JAMA Neurology, Ruben Smith and Oskar ...
COMMENT This is a brilliant study that shows us just how well Flortaucipir PET matches neuropathologically mapped tau. The correlations were strong as tested in a wide variety brain regions. The study clearly adds to our knowledge of Flortaucipir PET performance. ...
PAPER Braak H, Braak E7566337
PAPER Pfeffer RI, Kurosaki TT, Harrah CH Jr, Chance JM, Filos S7069156
PAPER Logsdon RG, Gibbons LE, McCurry SM, Teri L12021425
PAPER Teri L, Truax P, Logsdon R, Uomoto J, Zarit S, Vitaliano PP1466831
PAPER Sultzer DL, Berisford MA, Gunay I7473295
PAPER Yesavage JA, Brink TL, Rose TL, Lum O, Huang V, Adey M, Leirer VO7183759
PAPER Cohen-Mansfield J3760436
COMMENT Stunning achievement, combining genome-wide SNP analysis with RNA-Seq—protein-coding; pseudogenes; lncRNAs; sncRNAs—in 13 human immune cell types, primarily lymphocytes. Once cis eQTL, i.e., SNPs that affected expression of a gene on the same chromosome, ...
Richard Ransohoff on Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes.
COMMENT Microglial scRNA-Seq was performed across the mouse life span from E14.5 through P540. After cluster analysis, care was taken to specify at what age, and where, in the brain varied clusters were detected. It was observed that maximal microglial ...
PAPER Reisberg B3249767
COMMENT These are exciting findings, with implications for α-synuclein therapeutics and Parkinson's disease. Researchers have known that α-synuclein interacts with lipids for some time, but few therapeutic strategies have exploited this property. The two ...
PAPER Olah M, Menon V, Habib N, Taga M, Yung C, Cimpean M, Khairalla A, Dionne D, Hopp S, Frosch MP, Hyman BT, Beach TG, Sarkis R, Cosgrove GR, Helgager J, Golden JA, Pennell PB, Schneider JA, Bennett DA, Regev A, Elyaman W, Bradshaw EM, De Jager PL
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