VNA Care Network Palliative/Hospice careNeedham , United States
Massachusetts General Hospital & Harvard Medical School
RESEARCH NEWS 2019-01-21 Research News A paper published online today in Nature Medicine finds that in familial Alzheimer’s disease, blood levels of neurofilament light (NfL) rise 16 years before the predicted age of onset. Scientists led by Mathias Jucker, German Center for ...
PAPER Preische O, Schultz SA, Apel A, Kuhle J, Kaeser SA, Barro C, Gräber S, Kuder-Buletta E, LaFougere C, Laske C, Vöglein J, Levin J, Masters CL, Martins R, Schofield PR, Rossor MN, Graff-Radford NR, Salloway S, Ghetti B, Ringman JM, Noble JM, Chhatwal J, Goate AM, Benzinger TL, Morris JC, Bateman RJ, Wang G, Fagan AM, McDade EM, Gordon BA, Jucker M, Dominantly Inherited Alzheimer Network
UK DRI at the University of CambridgeCambridge, United Kingdom
HOUSTON, United States
RESEARCH NEWS 2019-01-19 Research News A paper in the January 15 Cell Reports suggests that tauopathies cause defects in nucleocytoplasmic transport. Scientists led by Rick Livesey, University College London, report that mutated tau gives rise to microtubules that prod neuronal ...
PAPER Kelley JB, Datta S, Snow CJ, Chatterjee M, Ni L, Spencer A, Yang CS, Cubeñas-Potts C, Matunis MJ, Paschal BM
The defective nuclear lamina in Hutchinson-gilford progeria syndrome disrupts the nucleocytoplasmic Ran gradient and inhibits nuclear localization of Ubc9.Mol Cell Biol. 2011 Aug;31(16):3378-95. Epub 2011 Jun 13 PubMed: 21670151
PAPER Broers JL, Ramaekers FC, Bonne G, Yaou RB, Hutchison CJ16816143
Baltimore, United States
Administrative Supplement for Research on Sex/Gender Influences (Admin Supp Clinical Trial Optional)
GRANT Friday, January 18, 2019- 21:15 National Institutes of Health The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications. The Office of Research on Women's Health (ORWH) intends to ...
COMMENT The investigators have to be congratulated for making a new major step in understanding the role of cerebral vascular pathology in cognitive decline. In subjects with and without mild cognitive impairment (MCI) they showed once more increases in blood ...
COMMENT The effects of Alzheimer’s pathology on brain vasculature is an important topic and this study demonstrates that vascular endothelial disruption and the breakdown of the BBB is influencing cognitive performance independent of Alzheimer’s-related pathology ...
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