Actin (3F10)

ANTIBODY monoclonal 3F10 manufacturer Cat# MA1-34935 immunogen = full length purified human actin liquid, PBS, glycerol, BSA, azide, protein G purified actin IgG₁ Actin Related A B R- Thermo Scientific Mouse Dog Chicken Human Mouse Rat Actin

Actin, muscle (HHF35)

ANTIBODY monoclonal HHF35 manufacturer Cat# MA1-82599 immunogen = muscle actin, purified from human myocardium liquid, supernatant, PBS, BSA, azide muscle specific alpha actin; does not recognize beta actin shrew IgG₁ Actin Related A B R- Th

Tracy Young-Pearse

Brigham and Women's Hospital and Harvard Medical School
Boston, United States

PAPER Maji SK, Perrin MH, Sawaya MR, Jessberger S, Vadodaria K, Rissman RA, Singru PS, Nilsson KP, Simon R, Schubert D, Eisenberg D, Rivier J, Sawchenko P, Vale W, Riek R

Functional amyloids as natural storage of peptide hormones in pituitary secretory granules.

Science. 2009 Jul 17;325(5938):328-32. PubMed: 19541956

PAPER Fowler DM, Koulov AV, Balch WE, Kelly JW

Functional amyloid--from bacteria to humans.

Trends Biochem Sci. 2007 May;32(5):217-24. PubMed: 17412596

Sylvain Lesne on The Toxic Fold? Aβ Dodecamers, Tetramers Show Their Conformations

COMMENT Two New Articles Use Synthetic Aβ to Study Oligomerization The first article by Bernstein et al. uses ion mobility coupled with mass spectrometry to study how Aβ40 and Aβ42 oligomerize in vitro. The measurements of arrival time distributions show that Aβ4

John Trojanowski on Transmission and spreading of tauopathy in transgenic mouse brain.

COMMENT This is a provocative and exceptionally well-done study that convincingly demonstrates the CNS spread of tau pathology induced by the injection of P301S transgenic (tg) mouse brain homogenates containing P301S pathological mutant tau into the brains of wi

PAPER Manuelidis EE, de Figueiredo JM, Kim JH, Fritch WW, Manuelidis L

Transmission studies from blood of Alzheimer disease patients and healthy relatives.

Proc Natl Acad Sci U S A. 1988 Jul;85(13):4898-901. PubMed: 3387446

PAPER Godec MS, Asher DM, Masters CL, Kozachuk WE, Friedland RP, Gibbs CJ, Gajdusek DC, Rapoport SI, Schapiro MB

Evidence against the transmissibility of Alzheimer's disease.

Neurology. 1991 Aug;41(8):1320. PubMed: 1866028

Paul Coleman on Enrichment and analysis of Alzheimer's Abeta1-42 peptide in human plasma and whole blood.

COMMENT This appears to be a significant improvement in methods to assay Aβ components in blood compartments because of its apparent increased sensitivity and also, perhaps more importantly, because it detects Aβ peptides in both fluid and cellular compartments o

Margaret Dabraccio on Betwixt and Intermixed—Dementia With Lewy Bodies

COMMENT Found the Webinar very interesting. We have a dual Parkinson's/AD diagnosis. I strongly suspect Lewy body disease. The decline over spring has been so rapid we are struggling and a little overwhelmed at times. mad127d 0

David Small on Interaction of reelin with amyloid precursor protein promotes neurite outgrowth.

COMMENT This very interesting paper provides another link in our understanding of the role of APP in synaptogenesis and Alzheimer's disease. Understanding the function of APP and its molecular partners (e.g., reelin) will undoubtedly provide key insights int

PAPER Clarris HJ, Key B, Beyreuther K, Masters CL, Small DH

Expression of the amyloid protein precursor of Alzheimer's disease in the developing rat olfactory system.

Brain Res Dev Brain Res. 1995 Aug 28;88(1):87-95. PubMed: 7493410

PAPER Williamson TG, Nurcombe V, Beyreuther K, Masters CL, Small DH

Affinity purification of proteoglycans that bind to the amyloid protein precursor of Alzheimer's disease.

J Neurochem. 1995 Nov;65(5):2201-8. PubMed: 7595508

PAPER Small DH, Nurcombe V, Reed G, Clarris H, Moir R, Beyreuther K, Masters CL

A heparin-binding domain in the amyloid protein precursor of Alzheimer's disease is involved in the regulation of neurite outgrowth.

J Neurosci. 1994 Apr;14(4):2117-27. PubMed: 8158260