PAPER Szodorai A, Kuan YH, Hunzelmann S, Engel U, Sakane A, Sasaki T, Takai Y, Kirsch J, Müller U, Beyreuther K, Brady S, Morfini G, Kins S
SEARCH RESULTS
331256 RESULTS
Kirti Bhatotia
India
Boris Schmidt on Modulation of gamma-secretase specificity using small molecule allosteric inhibitors.
COMMENT This is an interesting paper. The lead structure, hydroxycoumarin, is rapidly accessible and thus quite well known; SciFinder lists 560 close analogues covering 193 publications. The compound class is a frequent hitter in high throughput screening assays.
PAPER Rahman MH, Miyoshi T, Sukimoto K, Takadate A, Otagiri M
Interaction mode of dicumarol and its derivatives with human serum albumin, alpha 1-acid glycoprotein and asialo alpha 1-acid glycoprotein.
J Pharmacobiodyn. 1992 Jan;15(1):7-16. PubMed: 1376777PAPER Saíz-Urra L, González MP, Fall Y, Gómez G
Quantitative structure-activity relationship studies of HIV-1 integrase inhibition. 1. GETAWAY descriptors.
Eur J Med Chem. 2007 Jan;42(1):64-70. PubMed: 17030481PAPER Casañola-Martín GM, Marrero-Ponce Y, Tareq Hassan Khan M, Torrens F, Pérez-Giménez F, Rescigno A
Atom- and bond-based 2D TOMOCOMD-CARDD approach and ligand-based virtual screening for the drug discovery of new tyrosinase inhibitors.
J Biomol Screen. 2008 Dec;13(10):1014-24. PubMed: 19015291AD Biomarker Labs Can Get Standard Protocol, Quality Control
SERIES Did you know that if you had a spinal tap for a cerebrospinal fluid-based Alzheimer's diagnosis in Boston, Stockholm, London, or San Diego, the readout would likely be different in each place? And different again this year and next? That's a pro
PAPER Chen Y, Stankovic R, Cullen KM, Meininger V, Garner B, Coggan S, Grant R, Brew BJ, Guillemin GJ
The kynurenine pathway and inflammation in amyotrophic lateral sclerosis.
Neurotox Res. 2010 Aug;18(2):132-42. PubMed: 19921535PAPER Moreno-Igoa M, Calvo AC, Penas C, Manzano R, Oliván S, Muñoz MJ, Mancuso R, Zaragoza P, Aguilera J, Navarro X, Osta Pinzolas R
Fragment C of tetanus toxin, more than a carrier. Novel perspectives in non-viral ALS gene therapy.
J Mol Med (Berl). 2010 Mar;88(3):297-308. PubMed: 19921501Worldwide Quality Control of CSF Biomarkers—How Does it Work?
RESEARCH NEWS 2009-11-20 Research News Updated 22 November 2009 Part 1 in this series laid out the rationale for a new initiative called the Alzheimer’s Association QC Program for CSF Biomarkers, and Part 2 detailed the possible reasons why centers come up with such different res
Chicago: The Vampire Principle—Young Blood Rejuvenates Aging Brain?
CONFERENCE COVERAGE 2009-11-20 Conference Coverage Bram Stoker would have loved it. One hundred twelve years after the Irish author penned Dracula, his bone-chilling masterpiece, scientists at last month’s Society for Neuroscience conference in Chicago confirmed the vampire principle,
PAPER Ono Y, Gnocchi VF, Zammit PS, Nagatomi R
Presenilin-1 acts via Id1 to regulate the function of muscle satellite cells in a gamma-secretase-independent manner.
J Cell Sci. 2009 Dec 15;122(Pt 24):4427-38. PubMed: 19920078PAPER Salameh MA, Robinson JL, Navaneetham D, Sinha D, Madden BJ, Walsh PN, Radisky ES
The amyloid precursor protein/protease nexin 2 Kunitz inhibitor domain is a highly specific substrate of mesotrypsin.
J Biol Chem. 2010 Jan 15;285(3):1939-49. PubMed: 19920152PAPER Lapointe NE, Horowitz PM, Guillozet-Bongaarts AL, Silva A, Andreadis A, Binder LI
Tau 6D and 6P isoforms inhibit polymerization of full-length tau in vitro.
Biochemistry. 2009 Dec 29;48(51):12290-7. PubMed: 19919107PAPER Beckman M, Freeman C, Parish CR, Small DH
Activation of cathepsin D by glycosaminoglycans.
FEBS J. 2009 Dec;276(24):7343-52. PubMed: 19919557Current Filters
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