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Cerebrovascular Disease: Does Tau Mediate Cognitive Decline?

RESEARCH NEWS 2018-05-19 Research News The accumulation of neurofibrillary tangles tracks with cognitive impairment in Alzheimer’s disease, but what about other forms of dementia? The second most common cause of dementia, cerebrovascular disease, shrinks the brain’s blood supply ...

To Deliver Itself From Cell to Cell, Phospho-Tau Uses UPS

RESEARCH NEWS 2018-05-19 Research News When idle, tau may have nothing better to do than hitch a ride out of town. According to a study in the May 15 Cell Reports, phosphorylated tau, which can no longer bind microtubules, instead interacts with the inner leaflet of the plasma ...

Liver Tox Ends Janssen BACE Program

RESEARCH NEWS 2018-05-18 Research News And another one bites the dust. Yesterday, Janssen, the pharmaceutical division of Johnson & Johnson, announced that it would end clinical development of the BACE inhibitor atabecestat. Serious elevations in liver enzymes were detected ...

“Nanosweeper” Brushes Aβ into Cellular Dustbins

RESEARCH NEWS 2018-05-18 Research News Researchers have engineered the tiniest of brooms to tidy up the Aβ-strewn brain. In the May 4 Nature Communications, researchers led by Jing-Ping Zhang of Northeast Normal University in Changchun, China, and Lei Wang and Hao Wang, both of ...

No, TDP-43 and FUS Are Not Actively Exported From the Nucleus

RESEARCH NEWS 2018-05-18 Research News In amyotrophic lateral sclerosis and frontotemporal dementia, the nuclear RNA-binding proteins TDP-43 and FUS mislocalize to cytoplasm, where they aggregate and contribute to pathology. Because both proteins contain putative nuclear export ...

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