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229528 RESULTS

Surprise: HDAC Goes Down, Not Up, in Alzheimer’s Disease

CONFERENCE COVERAGE 2018-08-18 Conference Coverage As gene regulation changes in Alzheimer’s disease, scientists believe that histone deacetylases (HDACs) go into overdrive, shutting down transcription of certain genes. Consequently, several research groups are exploring the potential ...

Memory Slips as Soon as Amyloid Appears, Two Decades Before Dementia

CONFERENCE COVERAGE 2018-08-17 Conference Coverage How early in Alzheimer’s disease does a person’s memory falter? As soon as amyloid starts to build up, according to speakers at the Alzheimer’s Association International Conference in Chicago July 22–26. Even before an amyloid scan ...

Four Immunotherapies Now Banish Amyloid From the Brain

CONFERENCE COVERAGE 2018-08-17 Conference Coverage After years of fits and starts, anti-amyloid immunotherapies are finally hitting their target effectively. At least four drugs have now demonstrated the ability to clear plaques from the brain: aducanumab, gantenerumab, Lilly’s ...

In C9ORF72 Expansion Carriers, Protein Levels Drop in Cerebellum

RESEARCH NEWS 2018-08-17 Research News Hexanucleotide expansions in the C9ORF72 gene are the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), yet the physiological function of the protein remains a mystery. To address this gap, ...

Tardp_RRM2mut

RESEARCH MODELS Summary RRM2mut mice harbor the p.F210I mutation within RNA recognition motif 2 (RRM2) of the endogenous mouse Tardp gene.  This line was generated after screening DNA archives from two large-scale chemical mutagenesis projects (Acevedo-Arozena et al., ...

Tardp LCDmut

RESEARCH MODELS Summary LCDmut mice harbor the p.M323K mutation within the C-terminal low complexity domain (LCD) of the endogenous mouse Tardp gene. This line was generated after screening DNA archives from two large-scale chemical mutagenesis projects (Acevedo-Arozena ...

Tardbp Q331K Knock-In

RESEARCH MODELS Summary CRISPR/Cas9 was used to introduce the p.Q331K mutation into the mouse Tardp gene (Fratta et al., 2018). These mice can be used to study the effects of the p.Q331K mutation when TDP-43 is expressed at physiological levels, under the control of its ...

Largest AD Whole-Exome Study to Date Finds Two New Risk Genes

RESEARCH NEWS 2018-08-17 Research News From the depths of more than 20,000 whole-exome sequences, researchers from the Alzheimer’s Disease Sequencing Project (ADSP) hauled out two novel genetic variants that significantly associate with risk for late-onset AD: the zinc-finger ...

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