COMMENT I am puzzled by this experimental observation of supposedly beneficial effects of interference with CSF1-R function given the clinical syndrome of HDLS/POLG, a dementing condition due to CSF1-R loss-of-function mutations (e.g., Pridans, et al. 2013). ...
PAPER Pridans C, Sauter KA, Baer K, Kissel H, Hume DA24145216
COMMENT I agree with Dr. Geerts. Because the human nervous system is a complex system, complexity theory can and should be applied to the study of age-related neurodegenerative diseases. Complexity theory provides a framework that takes into account the ...
COMMENT The negative outcome of any trial in AD is always disappointing, especially since this is a second attempt and it is easy to dismiss this target for symptomatic pro-cognitive enhancement. However as with other examples, the pharmacodynamic interactions ...
Stanford, United States
Edith Cowan University, Curtin UniversityAustralia
Institute of NeurogeneticsLuebeck
Melbourne, United States
Amsterdam University CollegeAmsterdam, Netherlands
PAPER Archbold HC, Jackson KL, Arora A, Weskamp K, Tank EM, Li X, Miguez R, Dayton RD, Tamir S, Klein RL, Barmada SJ
TDP43 nuclear export and neurodegeneration in models of amyotrophic lateral sclerosis and frontotemporal dementia.Sci Rep. 2018 Mar 15;8(1):4606. PubMed: 29545601
PAPER Yoshikawa M, Soeda Y, Michikawa M, Almeida OF, Takashima A
Tau Depletion in APP Transgenic Mice Attenuates Task-Related Hyperactivation of the Hippocampus and Differentially Influences Locomotor Activity and Spatial Memory.Front Neurosci. 2018;12:124. Epub 2018 Mar 1 PubMed: 29545742
No filters selected