alpha 1-antitrypsin (AAT)(48D2)

ANTIBODY monoclonal manufacturer Cat# sc-69752 immunogen = purified human alpha-1-antitrypsin (AAT) liquid, PBS, azide alpha-1-antitrypsin (AAT); no reaction with alpha-1-antichymotrypsin (AACT) IgG₁ α-1-antitrypsin Santa Cruz Mouse Human Mo

alpha 1-antitrypsin (AAT)(13702)

ANTIBODY monoclonal manufacturer Cat# sc-73431 immunogen = human alpha-1-antitrypsin liquid, PBS, azide, gelatin alpha-1-antitrypsin (AAT); no reaction with alpha-1-antichymotrypsin (AACT) IgG₁ α-1-antitrypsin Santa Cruz Mouse Human alpha 1-

alpha 1-antitrypsin (AAT)(1.B.14)

ANTIBODY monoclonal manufacturer Cat# sc-69985 immunogen = human alpha-1-antitrypsin liquid, PBS, azide, gelatin alpha-1-antitrypsin (AAT); no reaction with alpha-1-antichymotrypsin (AACT) IgG_2a α-1-antitrypsin Santa Cruz Mouse Human alpha 1

14-3-3γ

ANTIBODY monoclonal manufacturer Cat# 53200 immunogen = recombinant 14.3.3-γ protein of human origin liquid, protein-G purified, PBS, BSA, azide 14-3-3gamma IgG₁, κ 14-3-3s Anaspec Rabbit Human 14-3-3γ http://alzforum.org/res/com/an

14-3-3σ

ANTIBODY monoclonal manufacturer Cat# 53201 immunogen = recombinant 14.3.3-σ protein of human origin liquid, protein-G purified, PBS, BSA, azide 14-3-3sigma IgG₁, κ 14-3-3s Anaspec Rabbit Human 14-3-3σ http://alzforum.org/res/com/an

Xiongwei Zhu on Cancer linked to Alzheimer disease but not vascular dementia.

COMMENT Comment by Hyoung-gon Lee, Xiongwei Zhu, Xinglong Wang, Rudy J. Castellani, George Perry, and Mark A. Smith Cancer, Alzheimer Disease, and Cardiovascular Disease: Associations and Disassociations—Clues to Etiology? There are numerous pathological similari

PAPER Lee HG, Chen Q, Wolfram JA, Richardson SL, Liner A, Siedlak SL, Zhu X, Ziats NP, Fujioka H, Felsher DW, Castellani RJ, Valencik ML, McDonald JA, Hoit BD, Lesnefsky EJ, Smith MA

Cell cycle re-entry and mitochondrial defects in myc-mediated hypertrophic cardiomyopathy and heart failure.

PLoS One. 2009;4(9):e7172. PubMed: 19779629

PAPER Narendra DP, Jin SM, Tanaka A, Suen DF, Gautier CA, Shen J, Cookson MR, Youle RJ

PINK1 is selectively stabilized on impaired mitochondria to activate Parkin.

PLoS Biol. 2010 Jan;8(1):e1000298. PubMed: 20126261

Xiongwei Zhu on Expression of beta-amyloid induced age-dependent presynaptic and axonal changes in Drosophila.

COMMENT Synaptic loss and mitochondrial dysfunction are both early features of Alzheimer disease, and connecting the two, as demonstrated in several recent studies including this present work, is attractive. Our recent work revealed that mitochondria accumulate i

PAPER Lutz AK, Exner N, Fett ME, Schlehe JS, Kloos K, Lämmermann K, Brunner B, Kurz-Drexler A, Vogel F, Reichert AS, Bouman L, Vogt-Weisenhorn D, Wurst W, Tatzelt J, Haass C, Winklhofer KF

Loss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation.

J Biol Chem. 2009 Aug 21;284(34):22938-51. PubMed: 19546216

Bingwei Lu on Expression of beta-amyloid induced age-dependent presynaptic and axonal changes in Drosophila.

COMMENT The authors described a new system to examine the effect of Aβ on neuronal morphogenesis and physiology in the adult fly brain. They observed depletion of mitochondria in neuronal processes in aged brain. Although the authors raised the possibility of mit

Bingwei Lu on PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1.

COMMENT The authors did a marvelous job in providing biochemical and cell biological evidence linking the Pink1/parkin pathway to mitochondrial autophagy. This adds significant new insights into the mechanisms by which the Pink1/parkin pathway regulates mitochond

CNPase (11-5B)

ANTIBODY monoclonal 11-5B manufacturer cat# MAB326<br />Reference: <br /><a href="/papers/neural-stem-cells-improve-cognition-bdnf-transgenic-model-alzheimer-disease" target="_new">Blurton-Jones, 2009</a> immunogen = pur

Galactocerebroside (mGalC)

ANTIBODY monoclonal mGalC manufacturer Cat# MAB342<br />Reference: <br /><a href="/papers/neural-stem-cells-improve-cognition-bdnf-transgenic-model-alzheimer-disease" target="_new">Blurton-Jones, 2009</a> immunogen = Syn

Lucia Chavez-Gutierrez on Gamma-secretase composed of PS1/Pen2/Aph1a can cleave notch and amyloid precursor protein in the absence of nicastrin.

COMMENT Zhao et al. present a novel and interesting set of findings that shed light on one of the most intriguing features of the γ-secretase enzyme: its dependence on the formation of a high-molecular-weight complex. This study provides further support for the i