PAPER Kessels RP, Rijken S, Joosten-Weyn Banningh LW, Van Schuylenborgh-VAN Es N, Olde Rikkert MG
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330988 RESULTS
PAPER Schwab C, Klegeris A, McGeer PL
Inflammation in transgenic mouse models of neurodegenerative disorders.
Biochim Biophys Acta. 2010 Oct;1802(10):889-902. PubMed: 19883753PAPER Ellefsen B, Holm-Pedersen P, Morse DE, Schroll M, Andersen BB, Waldemar G
Assessing caries increments in elderly patients with and without dementia: a one-year follow-up study.
J Am Dent Assoc. 2009 Nov;140(11):1392-400. PubMed: 19884398Mark Sager on Vascular factors and markers of inflammation in offspring with a parental history of late-onset Alzheimer disease.
COMMENT We have known for a long time that family history is a risk factor for the development of AD. This study is confirming what we and others are finding in our Wisconsin Registry for Alzheimer's Prevention (WRAP) cohort of middle-aged adult offspring of
Caleb (Tuck) Finch on Vascular factors and markers of inflammation in offspring with a parental history of late-onset Alzheimer disease.
COMMENT This new familial study of dementia in patients from the Memory Clinical of the Free University of Amsterdam (VU) brings to light further risk factors beyond the commonly studied ApoE alleles (C/R112). The study shows the expected twofold higher frequency
PAPER Stengård JH, Frikke-Schmidt R, Tybjaerg-Hansen A, Nordestgaard BG, Sing CF
Variation in 5' promoter region of the APOE gene contributes to predicting ischemic heart disease (IHD) in the population at large: the Copenhagen City Heart Study.
Ann Hum Genet. 2007 Nov;71(Pt 6):762-71. PubMed: 17535270PAPER Rivieccio MA, Brochier C, Willis DE, Walker BA, D'Annibale MA, McLaughlin K, Siddiq A, Kozikowski AP, Jaffrey SR, Twiss JL, Ratan RR, Langley B
HDAC6 is a target for protection and regeneration following injury in the nervous system.
Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19599-604. PubMed: 19884510PAPER Lorber B, Howe ML, Benowitz LI, Irwin N
Mst3b, an Ste20-like kinase, regulates axon regeneration in mature CNS and PNS pathways.
Nat Neurosci. 2009 Nov;12(11):1407-14. PubMed: 19855390PAPER Kadoya K, Tsukada S, Lu P, Coppola G, Geschwind D, Filbin MT, Blesch A, Tuszynski MH
Combined intrinsic and extrinsic neuronal mechanisms facilitate bridging axonal regeneration one year after spinal cord injury.
Neuron. 2009 Oct 29;64(2):165-72. PubMed: 19874785PAPER Hannila SS, Filbin MT
The role of cyclic AMP signaling in promoting axonal regeneration after spinal cord injury.
Exp Neurol. 2008 Feb;209(2):321-32. PubMed: 17720160PAPER Pearse DD, Pereira FC, Marcillo AE, Bates ML, Berrocal YA, Filbin MT, Bunge MB
cAMP and Schwann cells promote axonal growth and functional recovery after spinal cord injury.
Nat Med. 2004 Jun;10(6):610-6. PubMed: 15156204David Holtzman on Vascular factors and markers of inflammation in offspring with a parental history of late-onset Alzheimer disease.
COMMENT The findings in this paper are interesting. The finding that ApoE4 is much more frequent in offspring in which there was a parent with AD versus those without is predicted and is being found in virtually all studies. This is a very strong effect. The unex
PAPER van Exel E, Eikelenboom P, Comijs H, Frölich M, Smit JH, Stek ML, Scheltens P, Eefsting JE, Westendorp RG
Vascular factors and markers of inflammation in offspring with a parental history of late-onset Alzheimer disease.
Arch Gen Psychiatry. 2009 Nov;66(11):1263-70. PubMed: 19884614Christian Hoelscher on Research Brief: Diabetes—Risk Factor That Slows Cognitive Decline?
COMMENT This is indeed a confusing result, as previous large-scale studies have shown an increased risk of type 2 diabetes mellitus patients for developing AD, for example, the recent study by Xu et al., 2009. One important confounding variable is, Are the T2DM p
Gerardo Gregory M D on Research Brief—Flurizan Fails Final Hurdle, Company Discontinues Drug
COMMENT Outstanding information. shrinktt1 0
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