COMMENT The paper by Zhao and colleagues reports that Trem2 is a receptor for Aβ, joining a long list of cell surface Aβ-binding proteins on microglia. The authors argue that Trem2 preferentially interacts with Aβ oligomers, with Kd’s in the nM range. A point of ...
PAPER Abbasi J29536076
Broad InstituteCambridge, United States
RESEARCH NEWS 2018-03-22 Research News A new CRISPR tool proves that good things do sometimes come in small packages. Patrick Hsu and colleagues at the Salk Institute in La Jolla, California, identified a family of bacterial RNA-guided, RNA-selective nucleases. Considerably ...
PAPER Yan WX, Chong S, Zhang H, Makarova KS, Koonin EV, Cheng DR, Scott DA
Cas13d Is a Compact RNA-Targeting Type VI CRISPR Effector Positively Modulated by a WYL-Domain-Containing Accessory Protein.Mol Cell. 2018 Mar 9; PubMed: 29551514
PAPER Konermann S, Lotfy P, Brideau NJ, Oki J, Shokhirev MN, Hsu PD29551272
Albany Medical CollegeAlbany, United States
New York, United States
Alzheimers Research UK Cambridge Drug Discovery InstituteUnited Kingdom
PAPER Houmani N, Vialatte F, Gallego-Jutglà E, Dreyfus G, Nguyen-Michel VH, Mariani J, Kinugawa K29558517
PAPER Jayakody DM, Friedland PL, Martins RN, Sohrabi HR29556173
PAPER Haller S, Vernooij MW, Kuijer JP, Larsson EM, Jäger HR, Barkhof F29558307
PAPER Lee MC, Yu WC, Shih YH, Chen CY, Guo ZH, Huang SJ, Chan JC, Chen YR
Zinc ion rapidly induces toxic, off-pathway amyloid-β oligomers distinct from amyloid-β derived diffusible ligands in Alzheimer's disease.Sci Rep. 2018 Mar 19;8(1):4772. PubMed: 29555950
No filters selected