PAPER Davis C, Heidler-Gary J, Gottesman RF, Crinion J, Newhart M, Moghekar A, Soloman D, Rigamonti D, Cloutman L, Hillis AE
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PAPER Kanaya K, Abe S, Sakai M, Fujii H, Iwamoto T
Changes in cognitive functions of patients with dementia of the Alzheimer type following long-term administration of donepezil hydrochloride: relating to changes attributable to differences in apolipoprotein E phenotype.
Geriatr Gerontol Int. 2010 Jan;10(1):25-31. PubMed: 20102379PAPER Gray HL, Jimenez DE, Cucciare MA, Tong HQ, Gallagher-Thompson D
Ethnic differences in beliefs regarding Alzheimer disease among dementia family caregivers.
Am J Geriatr Psychiatry. 2009 Nov;17(11):925-33. PubMed: 20104051PAPER Delaloye C, de Bilbao F, Moy G, Baudois S, Weber K, Campos L, Canuto A, Giardini U, von Gunten A, Stancu RI, Scheltens P, Lazeyras F, Millet P, Giannakopoulos P, Gold G
Neuroanatomical and neuropsychological features of euthymic patients with bipolar disorder.
Am J Geriatr Psychiatry. 2009 Dec;17(12):1012-21. PubMed: 20104058PAPER Panza F, Frisardi V, Capurso C, D'Introno A, Colacicco AM, Imbimbo BP, Santamato A, Vendemiale G, Seripa D, Pilotto A, Capurso A, Solfrizzi V
Late-life depression, mild cognitive impairment, and dementia: possible continuum?
Am J Geriatr Psychiatry. 2010 Feb;18(2):98-116. PubMed: 20104067PAPER Jones RN, Fong TG, Metzger E, Tulebaev S, Yang FM, Alsop DC, Marcantonio ER, Cupples LA, Gottlieb G, Inouye SK
Aging, brain disease, and reserve: implications for delirium.
Am J Geriatr Psychiatry. 2010 Feb;18(2):117-27. PubMed: 20104068PAPER Joling KJ, van Hout HP, Schellevis FG, van der Horst HE, Scheltens P, Knol DL, van Marwijk HW
Incidence of depression and anxiety in the spouses of patients with dementia: a naturalistic cohort study of recorded morbidity with a 6-year follow-up.
Am J Geriatr Psychiatry. 2010 Feb;18(2):146-53. PubMed: 20104070PAPER Lavretsky H, Siddarth P, Irwin MR
Improving depression and enhancing resilience in family dementia caregivers: a pilot randomized placebo-controlled trial of escitalopram.
Am J Geriatr Psychiatry. 2010 Feb;18(2):154-62. PubMed: 20104071PAPER Blay SL, Toledo Pisa Peluso E
Public stigma: the community's tolerance of Alzheimer disease.
Am J Geriatr Psychiatry. 2010 Feb;18(2):163-71. PubMed: 20104072Carla Yuede on Physical exercise, aging, and mild cognitive impairment: a population-based study.
COMMENT This study correlates exercise with decreased odds of developing MCI, which suggests a protective effect of exercise, especially moderate exercise. The observation that moderate exercise performed at either mid- or late life decreased the odds of having M
Carla Yuede on Effects of aerobic exercise on mild cognitive impairment: a controlled trial.
COMMENT This is a very interesting study examining the effects of exercise on multiple variables, both cognitive and physiological. Although the sample sizes are small, the strict exclusion criteria allow for more control. The authors use several cognitive measur
Jürgen Götz on Differential effects of Tau on the integrity and function of neurons essential for learning in Drosophila.
COMMENT This is interesting, also in the context of the Steinhilb/Feany publication (which is discussed in the article) on concerted action of tau phosphorylation sites rather than specific sites playing a role. 0 j.goetz
Virgil Muresan on Inside Out—Plaques May Have Intracellular Origin
COMMENT Two papers published recently in PNAS (1,2) touch an issue close to our hearts: the nucleation of neuritic plaques in Alzheimer disease. The most important issue about the seeded polymerization hypothesis (3) at this time is the nature of the “bad” seed t
Vincent Marchesi on Inside Out—Plaques May Have Intracellular Origin
COMMENT Two things about this study puzzle me. I don’t understand why the uptake of Aβ peptides by macrophages in culture necessarily mimics the development of plaques in the brains of AD patients, or why it is even a good model system. The claim that internalize
Jürgen Götz on Is abnormal axonal transport a cause, a contributing factor or a consequence of the neuronal pathology in Alzheimer's disease?
COMMENT The authors state that “perturbation of the transport of a limited set of proteins has been occasionally reported for other neurodegenerative diseases [than Alzheimer's].” In fact, we have shown that the anterograde transport of distinct cargos is im
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