COMMENT Like others in the field, I was disappointed to read about the external data monitoring committee’s (eDMC’s) finding that the BACE inhibitor verubecestat was unlikely to demonstrate “a positive benefit/risk” if the APECS study was completed in persons ...
RESEARCH NEWS 2018-02-16 Research News Many proteins involved in neurodegeneration have a penchant to undergo liquid phase separation, where they coalesce into highly concentrated fluid droplets. These dynamic and reversible assemblies have important physiological functions, but ...
PAPER Hughes MP, Sawaya MR, Boyer DR, Goldschmidt L, Rodriguez JA, Cascio D, Chong L, Gonen T, Eisenberg DS29439243
PAPER Shin Y, Brangwynne CP28935776
RESEARCH NEWS 2018-02-16 Research News With the realization that microglia play a key role in neurodegenerative conditions, scientists have profiled their transcription patterns to see how they change during disease. A study published in the January 16 Cell Reports pulls together ...
RESEARCH NEWS 2018-02-16 Research News Scientists have tried enhancing memory by modulating neurons in the brain, to little success. In the February 6 Nature Communications, researchers led by Michael Kahana and Daniel Rizzuto, University of Pennsylvania, Philadelphia, scored a ...
PAPER Jacobs J, Miller J, Lee SA, Coffey T, Watrous AJ, Sperling MR, Sharan A, Worrell G, Berry B, Lega B, Jobst BC, Davis K, Gross RE, Sheth SA, Ezzyat Y, Das SR, Stein J, Gorniak R, Kahana MJ, Rizzuto DS27930911
PAPER Ezzyat Y, Wanda PA, Levy DF, Kadel A, Aka A, Pedisich I, Sperling MR, Sharan AD, Lega BC, Burks A, Gross RE, Inman CS, Jobst BC, Gorenstein MA, Davis KA, Worrell GA, Kucewicz MT, Stein JM, Gorniak R, Das SR, Rizzuto DS, Kahana MJ29410414
PAPER Ezzyat Y, Kragel JE, Burke JF, Levy DF, Lyalenko A, Wanda P, O'Sullivan L, Hurley KB, Busygin S, Pedisich I, Sperling MR, Worrell GA, Kucewicz MT, Davis KA, Lucas TH, Inman CS, Lega BC, Jobst BC, Sheth SA, Zaghloul K, Jutras MJ, Stein JM, Das SR, Gorniak R, Rizzuto DS, Kahana MJ28434860
PAPER Wang BJ, Wu PY, Chen YW, Chang YT, Bhore N, Wu PF, Liao YF
Quantitative Measurement of γ-Secretase-mediated Amyloid Precursor Protein and Notch Cleavage in Cell-based Luciferase Reporter Assay Platforms.J Vis Exp. 2018 Jan 25;(131) PubMed: 29443039
PAPER Ogaki K, Martens YA, Heckman MG, Koga S, Labbé C, Lorenzo-Betancor O, Wernick AI, Walton RL, Soto AI, Vargas ER, Nielsen HM, Fujioka S, Kanekiyo T, Uitti RJ, van Gerpen JA, Cheshire WP, Wszolek ZK, Low PA, Singer W, Dickson DW, Bu G, Ross OA29442376
PAPER Daniele S, Pietrobono D, Fusi J, Lo Gerfo A, Cerri E, Chico L, Iofrida C, Petrozzi L, Baldacci F, Giacomelli C, Galetta F, Siciliano G, Bonuccelli U, Trincavelli ML, Franzoni F, Martini C
α-Synuclein Aggregated with Tau and β-Amyloid in Human Platelets from Healthy Subjects: Correlation with Physical Exercise.Front Aging Neurosci. 2018;10:17. Epub 2018 Jan 30 PubMed: 29441013
PAPER Hashimoto M, Ho G, Sugama S, Takamatsu Y, Shimizu Y, Takenouchi T, Waragai M, Masliah E29439348
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