PAPER Oliveira M, Torquato RJ, Alves MF, Juliano MA, Brömme D, Barros NM, Carmona AK
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PAPER McCurry SM, Gibbons LE, Logsdon RG, Vitiello MV, Teri L
Insomnia In Caregivers Of Persons With Dementia: Who Is At Risk And What Can Be Done About It?
Sleep Med Clin. 2009 Dec 1;4(4):519-526. PubMed: 20046806PAPER Ringman JM, Pope W, Salamon N
Insensitivity of visual assessment of hippocampal atrophy in familial Alzheimer's disease.
J Neurol. 2010 May;257(5):839-42. PubMed: 20047059PAPER Sabbagh MN, Shill HA
Latrepirdine, a potential novel treatment for Alzheimer's disease and Huntington's chorea.
Curr Opin Investig Drugs. 2010 Jan;11(1):80-91. PubMed: 20047162PAPER Gubitz AK, Gwinn K
Mining the genome for susceptibility to complex neurological disorders.
Curr Mol Med. 2009 Sep;9(7):801-13. PubMed: 19860660PAPER Grimaldi M, Scrima M, Esposito C, Vitiello G, Ramunno A, Limongelli V, D'Errico G, Novellino E, D'Ursi AM
Membrane charge dependent states of the beta-amyloid fragment Abeta (16-35) with differently charged micelle aggregates.
Biochim Biophys Acta. 2010 Mar;1798(3):660-71. PubMed: 20045392Sanjay Pimplikar on Novel mediators of amyloid precursor protein signaling.
COMMENT This study from Dale Bredesen’s group identifies TAZ and YAP as two potential downstream agents of APP-modulated gene transcription in a luciferase-reporter system. Since the γ-secretase inhibitor DAPT blocks the reporter activity, the authors suggest tha
Presenilin-1
ANTIBODY polyclonal manufacturer Cat# PRS4203 immunogen = a 23 amino acid peptide from near the carboxy-terminus of human presenilin1 liquid, buffered aqueous solution, affinity isolated, PBS, azide detects presenilin 1 γ-secretase/ Presenilins Sigma Aldrich Rabbi
Nicastrin (ab-2)
ANTIBODY polyclonal manufacturer Cat# PRS3985 immunogen = an 18 amino acid peptide from near the center of human Nicastrin buffered aqueous solution, affinity isolated, PBS, azide detects Nicastrin γ-secretase/ Presenilins Sigma Aldrich Rabbit Human Mouse Rat Nica
Nicastrin (ab-1)
ANTIBODY polyclonal manufacturer Cat# PRS3983 immunogen = a 17 amino acid peptide from near the C-terminus of human Nicastrin buffered aqueous solution, IgG fract, PBS, azide detects Nicastrin γ-secretase/ Presenilins Sigma Aldrich Rabbit Human Mouse Rat Nicastrin
GluR1
ANTIBODY polyclonal manufacturer Cat# 07-660 Immunogen = KLH-conjugated, synthetic peptide (C-RDHTR VDWKRPK) corresp. to aa. 276-287 of rat glutamate receptor 1 (GluR1), with a cysteine added for conjugation liquid, protein-A purified, Tris-Glycine, saline, glycer
GluR1 (EPR2148)
ANTIBODY monoclonal EPR2148 manufacturer Cat# 04-1073 Immunogen = phospho-specific peptide corresponding to residues surrounding Ser845 of human GluR1 liquid, unpurified, Tris-Glycine, saline, glycerol, azide, BSA recognizes GluR1 phosphorylated on Ser845; ~106 kD
Barry Wheeler
Cashcows Marketing INCKissimmee, United States
Nathalie Breysse
Lundbeck Research USA, Inc.Paramus, United States
Ruth Itzhaki on CSF biomarkers of Alzheimer disease in HIV-associated neurologic disease.
COMMENT The similarity, or otherwise, of HIV-associated neurologic disease to dementia of the Alzheimer’s type (DAT) seems as vexed a topic as that of an ApoE-ε4 association (or not) with HIV dementia or HIV encephalitis. In this paper, Clifford et al. (1), like
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