COMMENT It is exciting to see the research community pursue anti-oligomer drug discovery and follow up on the original findings that LilrB2 is part of the oligomer receptor complex. It is a reflection of the renewed interest in the Aβ oligomer hypothesis and the ...
COMMENT In this paper, researchers led by Jiang and Eisenberg identified an Aβ oligomer binding site on the LilrB2 receptor, a noncanonical major histocompatibility complex class I immune receptor implicated in amyloid-mediated synaptotoxicity (Kim et al., 2013). ...
COMMENT The study is well-done, which is not surprising considering who did it. The authors are quite properly cautious about the long-term therapeutic implications since their molecule is a long way from being a drug; nevertheless, many projects have begun this ...
PAPER Desmarais WT, Bienvenue DL, Bzymek KP, Holz RC, Petsko GA, Ringe D
The 1.20 A resolution crystal structure of the aminopeptidase from Aeromonas proteolytica complexed with tris: a tale of buffer inhibition.Structure. 2002 Aug;10(8):1063-72. PubMed: 12176384
PAPER Harrison DH, Bohren KM, Ringe D, Petsko GA, Gabbay KH
An anion binding site in human aldose reductase: mechanistic implications for the binding of citrate, cacodylate, and glucose 6-phosphate.Biochemistry. 1994 Mar 1;33(8):2011-20. PubMed: 8117658
PAPER Schlenzig D, Cynis H, Hartlage-Rübsamen M, Zeitschel U, Menge K, Fothe A, Ramsbeck D, Spahn C, Wermann M, Roßner S, Buchholz M, Schilling S, Demuth HU
Dipeptidyl-Peptidase Activity of Meprin β Links N-truncation of Aβ with Glutaminyl Cyclase-Catalyzed pGlu-Aβ Formation.J Alzheimers Dis. 2018 Sep 29; PubMed: 30320570
PAPER Martineau É, Di Polo A, Vande Velde C, Robitaille R30320556
PAPER Manousakis JE, Scovelle AJ, Rajaratnam SM, Naismith SL, Anderson C
Advanced Circadian Timing and Sleep Fragmentation Differentially Impact on Memory Complaint Subtype in Subjective Cognitive Decline.J Alzheimers Dis. 2018 Oct 6; PubMed: 30320584
PAPER Bruun M, Rhodius-Meester HF, Koikkalainen J, Baroni M, Gjerum L, Lemstra AW, Barkhof F, Remes AM, Urhemaa T, Tolonen A, Rueckert D, van Gils M, Frederiksen KS, Waldemar G, Scheltens P, Mecocci P, Soininen H, Lötjönen J, Hasselbalch SG, van der Flier WM30320203
PAPER Morello G, Spampinato AG, Conforti FL, Cavallaro S30319346
PAPER Bos MM, Noordam R, Blauw GJ, Slagboom PE, Rensen PC, van Heemst D30321297
PAPER Nguyen TP, Schaffert J, LoBue C, Womack KB, Hart J, Cullum CM30320582
PAPER Hartry A, Aldhouse NV, Al-Zubeidi T, Sanon M, Stefanacci RG, Knight SL
The conceptual relevance of assessment measures in patients with mild/mild-moderate Alzheimer's disease.Alzheimers Dement (Amst). 2018;10:498-508. Epub 2018 Aug 10 PubMed: 30320202
PAPER Connors MH, Quinto L, Brodaty H30319082
PAPER Chun H, Marriott I, Lee CJ, Cho H
Elucidating the Interactive Roles of Glia in Alzheimer's Disease Using Established and Newly Developed Experimental Models.Front Neurol. 2018;9:797. Epub 2018 Sep 26 PubMed: 30319529
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