GRANT Wednesday, July 18, 2018- 14:30 Alzheimer's Drug Discovery Foundation Letter of Intent Deadline: September 14, 2018 Diagnostics Accelerator: Peripheral Biomarkers Program ...
COMMENT Genome editing is a potentially powerful approach for knocking out disease-causing genes, repairing genes whose mutations have resulted in a loss of function, or safely inserting therapeutic genes into the host cell genome. It is very important to ...
COMMENT This data from Allan Bradley and colleagues suggest there could be problems using CRISPRs in dividing cells, because the authors found large deletions and more complex genomic rearrangements at targeted sites. Though it has been long recognized that ...
GRANT Wednesday, July 18, 2018- 08:15 Nathan Shock Center for Excellence in the Basic Biology of Aging Opportunities for phenotyping, intervention testing, and tissue collection with aged mice require advanced planning. Applications received by October 1, 2018 ...
RESEARCH NEWS 2018-07-18 Research News The power of CRISPR to delete or replace specific genes has quickly made it the go-to gene-editing tool, now in use in several clinical trials. But is this genomic manipulation as specific as people think? In the July 16 Nature Biotechnology ...
PAPER Kosicki M, Tomberg K, Bradley A
Repair of double-strand breaks induced by CRISPR-Cas9 leads to large deletions and complex rearrangements.Nat Biotechnol. 2018 Jul 16; PubMed: 30010673
PAPER Hendel A, Bak RO, Clark JT, Kennedy AB, Ryan DE, Roy S, Steinfeld I, Lunstad BD, Kaiser RJ, Wilkens AB, Bacchetta R, Tsalenko A, Dellinger D, Bruhn L, Porteus MH26121415
PAPER van Overbeek M, Capurso D, Carter MM, Thompson MS, Frias E, Russ C, Reece-Hoyes JS, Nye C, Gradia S, Vidal B, Zheng J, Hoffman GR, Fuller CK, May AP27499295
PAPER Tan EP, Li Y, Velasco-Herrera Md, Yusa K, Bradley A25378133
PAPER Koike-Yusa H, Li Y, Tan EP, Velasco-Herrera Md, Yusa K
Genome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA library.Nat Biotechnol. 2014 Mar;32(3):267-73. Epub 2013 Dec 23 PubMed: 24535568
JOB 2018-07-18 Employer Chan Zuckerberg Initiative Description The science team is seeking a science program anager to support CZI's efforts around neurodegenerative disease through the Neurodegeneration Challenge Network. The goal for this project is to develop a ...
PAPER Sánchez-Benavides G, Grau-Rivera O, Cacciaglia R, Suárez-Calvet M, Falcon C, Minguillon C, Gramunt N, Sala-Vila A, Domingo Gispert J, Luis Molinuevo J
Distinct Cognitive and Brain Morphological Features in Healthy Subjects Unaware of Informant-Reported Cognitive Decline.J Alzheimers Dis. 2018 Jul 10; PubMed: 30010134
PAPER René Thyrian J, Hertel J, N Schulze L, Dörr M, Prüss H, Hempel P, Bimmler M, Kunze R, Jörgen Grabe H, Teipel S, Hoffmann W
Prevalence and Determinants of Agonistic Autoantibodies Against α1-Adrenergic Receptors in Patients Screened Positive for Dementia: Results from the Population-Based DelpHi-Study.J Alzheimers Dis. 2018 Jun 27; PubMed: 30010118
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