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Gregory Cole on Rac Your Brain to Forget?
COMMENT This fly paper catches genetic evidence that Rac inhibition slows memory decay, constitutively increased Rac activation accelerates memory decay, and that cofilin hyperactivation gives rise to the same phenotype as seen with Rac inhibition. The authors co
PAPER Davis RL
Rac in the act of forgetting.
Cell. 2010 Feb 19;140(4):456-8. PubMed: 20178738PAPER Shuai Y, Lu B, Hu Y, Wang L, Sun K, Zhong Y
Forgetting is regulated through Rac activity in Drosophila.
Cell. 2010 Feb 19;140(4):579-89. PubMed: 20178749Varsha Shukla
NIHBethesda, United States
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The effect of silybin on passive avoidance learning and pathological changes in hippocampal CA1 and DG regions in male Wistar rats offspring.
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Lipid-mediated cell signaling protects against injury and neurodegeneration.
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The methodology of neuroproteomics.
Methods Mol Biol. 2009;566:1-21. PubMed: 20058161Rac Your Brain to Forget?
RESEARCH NEWS 2010-02-27 Research News It can be a good thing to forget, especially when learned information becomes useless or overly troubling. Yet the mechanisms by which we forget are a mystery: Is forgetting a passive reversal of learning, or must the brain make an effort to
CaMKII: More Than Just an Enzyme; It’s a Scaffold, Too
RESEARCH NEWS 2010-02-27 Research News To form and cement memories, the synapse must restructure itself, breaking down some proteins and rebuilding new configurations. The proteasome, which mediates the breakdown process, migrates into post-synaptic regions following nerve stimul
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