Bingwei Lu on Expression of beta-amyloid induced age-dependent presynaptic and axonal changes in Drosophila.

COMMENT The authors described a new system to examine the effect of Aβ on neuronal morphogenesis and physiology in the adult fly brain. They observed depletion of mitochondria in neuronal processes in aged brain. Although the authors raised the possibility of mit

Bingwei Lu on PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1.

COMMENT The authors did a marvelous job in providing biochemical and cell biological evidence linking the Pink1/parkin pathway to mitochondrial autophagy. This adds significant new insights into the mechanisms by which the Pink1/parkin pathway regulates mitochond

CNPase (11-5B)

ANTIBODY monoclonal 11-5B manufacturer cat# MAB326<br />Reference: <br /><a href="/papers/neural-stem-cells-improve-cognition-bdnf-transgenic-model-alzheimer-disease" target="_new">Blurton-Jones, 2009</a> immunogen = pur

Galactocerebroside (mGalC)

ANTIBODY monoclonal mGalC manufacturer Cat# MAB342<br />Reference: <br /><a href="/papers/neural-stem-cells-improve-cognition-bdnf-transgenic-model-alzheimer-disease" target="_new">Blurton-Jones, 2009</a> immunogen = Syn

Lucia Chavez-Gutierrez on Gamma-secretase composed of PS1/Pen2/Aph1a can cleave notch and amyloid precursor protein in the absence of nicastrin.

COMMENT Zhao et al. present a novel and interesting set of findings that shed light on one of the most intriguing features of the γ-secretase enzyme: its dependence on the formation of a high-molecular-weight complex. This study provides further support for the i

Lucia Chavez-Gutierrez

K.U.Leuven and V.I.B.
Leuven, Belgium

PAPER Zhao G, Liu Z, Ilagan MX, Kopan R

Gamma-secretase composed of PS1/Pen2/Aph1a can cleave notch and amyloid precursor protein in the absence of nicastrin.

J Neurosci. 2010 Feb 3;30(5):1648-56. PubMed: 20130175

PAPER Van Langenhove T, van der Zee J, Sleegers K, Engelborghs S, Vandenberghe R, Gijselinck I, Van den Broeck M, Mattheijssens M, Peeters K, De Deyn PP, Cruts M, Van Broeckhoven C

Genetic contribution of FUS to frontotemporal lobar degeneration.

Neurology. 2010 Feb 2;74(5):366-71. PubMed: 20124201

PAPER Dietz KC, Casaccia P

HDAC inhibitors and neurodegeneration: at the edge between protection and damage.

Pharmacol Res. 2010 Jul;62(1):11-7. PubMed: 20123018

PAPER Chen L, Wang H, Zhang Z, Li Z, He D, Sokabe M

DMXB (GTS-21) ameliorates the cognitive deficits in beta amyloid(25-35(-)) injected mice through preventing the dysfunction of alpha7 nicotinic receptor.

J Neurosci Res. 2010 Jun;88(8):1784-94. PubMed: 20127813

PAPER Taymans JM, Cookson MR

Mechanisms in dominant parkinsonism: The toxic triangle of LRRK2, alpha-synuclein, and tau.

Bioessays. 2010 Mar;32(3):227-35. PubMed: 20127702

PAPER Morimoto N, Nagai M, Miyazaki K, Ohta Y, Kurata T, Takehisa Y, Ikeda Y, Matsuura T, Asanuma M, Abe K

Induction of parkinsonism-related proteins in the spinal motor neurons of transgenic mouse carrying a mutant SOD1 gene.

J Neurosci Res. 2010 Jun;88(8):1804-11. PubMed: 20127819

PAPER Shi ZH, Nie G, Duan XL, Rouault T, Wu WS, Ning B, Zhang N, Chang YZ, Zhao BL

Neuroprotective mechanism of mitochondrial ferritin on 6-hydroxydopamine-induced dopaminergic cell damage: implication for neuroprotection in Parkinson's disease.

Antioxid Redox Signal. 2010 Sep 15;13(6):783-96. PubMed: 20121342

PAPER Pasquali L, Ruggieri S, Murri L, Paparelli A, Fornai F

Does autophagy worsen or improve the survival of dopaminergic neurons?

Parkinsonism Relat Disord. 2009 Dec;15 Suppl 4:S24-7. PubMed: 20123552

PAPER van den Berge SA, Middeldorp J, Zhang CE, Curtis MA, Leonard BW, Mastroeni D, Voorn P, van de Berg WD, Huitinga I, Hol EM

Longterm quiescent cells in the aged human subventricular neurogenic system specifically express GFAP-delta.

Aging Cell. 2010 Jun;9(3):313-26. PubMed: 20121722