COMMENT These are exciting findings, with implications for α-synuclein therapeutics and Parkinson's disease. Researchers have known that α-synuclein interacts with lipids for some time, but few therapeutic strategies have exploited this property. The two ...
PAPER Olah M, Menon V, Habib N, Taga M, Yung C, Cimpean M, Khairalla A, Dionne D, Hopp S, Frosch MP, Hyman BT, Beach TG, Sarkis R, Cosgrove GR, Helgager J, Golden JA, Pennell PB, Schneider JA, Bennett DA, Regev A, Elyaman W, Bradshaw EM, De Jager PL
PAPER Lawton MP, Brody EM5349366
PAPER Giera S, Luo R, Ying Y, Ackerman SD, Jeong SJ, Stoveken HM, Folts CJ, Welsh CA, Tall GG, Stevens B, Monk KR, Piao X
Microglial transglutaminase-2 drives myelination and myelin repair via GPR56/ADGRG1 in oligodendrocyte precursor cells.Elife. 2018 May 29;7 PubMed: 29809138
PAPER Hagemeyer N, Hanft KM, Akriditou MA, Unger N, Park ES, Stanley ER, Staszewski O, Dimou L, Prinz M
Microglia contribute to normal myelinogenesis and to oligodendrocyte progenitor maintenance during adulthood.Acta Neuropathol. 2017 Sep;134(3):441-458. Epub 2017 Jul 6 PubMed: 28685323
Shane Liddelow on Complement C3aR Inactivation Attenuates Tau Pathology and Reverses an Immune Network Deregulated in Tauopathy Models and Alzheimer's Disease.
COMMENT I have an academic soft spot for this study, as it perfectly validates some of our original findings on neurotoxic A1 reactive astrocytes in human AD and rodent tau models (Liddelow et al., 2018; Shi et al., 2018). In extensive work, Hui Zheng’s lab ...
PAPER Saxton J, Swihart AA2680032
COMMENT The Schmiedel et al. paper offers similar highlights to those found in Hammond et al.: Sex differences. Disease differences, though this time done by comparing cell-type specific transcriptome data sets with already-available GWAS data sets. Done in ...
PAPER Li Q, Cheng Z, Zhou L, Darmanis S, Neff N, Okamoto J, Gulati G, Bennett ML, Sun LO, Clarke LE, Marschallinger J, Yu G, Quake SR, Wyss-Coray T, Barres BA
CONFERENCE 2019-02-20 00:00:00-2019-02-20 00:00:00 New York, New York 20 February 2019 View Conference Website 1 ...
Shane Liddelow on Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes.
COMMENT This is a very exciting piece of research. I’ve eagerly awaited these data sets. A few points that make this work so novel, and will ensure that it is cited widely in the coming years: Single-cell microglia analysis—obviously interesting and follows ...
Syracuse, United States
Ramaiah University of Applied SciencesBangalore , India
PAPER Adriana AA, Armando LL, López-Diazguerrero NE, Mina K
The Effect of MPP+ on the Viability of Primary Cortical Astrocytes Isolated from Female and Male Wistar Rats of Different Ages.Cell Mol Neurobiol. 2018 Dec 11; PubMed: 30539419
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