One Dose Versus Slow Drip—It Matters for BDNF

RESEARCH NEWS 2010-02-26 Research News Many drugs come as a shot or a pill—one dose, all at once. Similarly, when cell biologists want to examine a growth factor in culture, they squirt on the full amount in one pipette load. But growth factor concentrations may not swing so shar

Phoenix: Can Alzheimer’s Prevention Initiative Break a Catch-22?

CONFERENCE COVERAGE 2010-02-26 Conference Coverage Last month, a one-day gathering of some 50 representatives of a range of international pharmaceutical companies, academic research leaders, funding representatives, and regulatory advisers ended with verbal support for the Alzheimer’s

PAPER Case M, Soltesz I

Discreet charm of the GABAergic bourgeoisie: superconnected cells conduct developmental symphonies.

Neuron. 2009 Dec 24;64(6):780-2. PubMed: 20064385

PAPER de Wit J, Sylwestrak E, O'Sullivan ML, Otto S, Tiglio K, Savas JN, Yates JR, Comoletti D, Taylor P, Ghosh A

LRRTM2 interacts with Neurexin1 and regulates excitatory synapse formation.

Neuron. 2009 Dec 24;64(6):799-806. PubMed: 20064388

PAPER Karaer S, Tarhan C, Pekmez M, Hamad I, Arda N, Sarikaya AT

Expression of human A4V mutant Cu,Zn superoxide dismutase in Schizosaccharomyces pombe: investigations of its toxic properties.

Biochem Genet. 2010 Feb;48(1-2):113-24. PubMed: 20094844

PAPER Ebrahim AS, Ko LW, Yen SH

Reduced expression of peroxisome-proliferator activated receptor gamma coactivator-1alpha enhances alpha-synuclein oligomerization and down regulates AKT/GSK3beta signaling pathway in human neuronal cells that inducibly express alpha-synuclein.

Neurosci Lett. 2010 Apr 5;473(2):120-5. PubMed: 20178833

PAPER Snyder BR, Chiu AM, Prockop DJ, Chan AW

Human multipotent stromal cells (MSCs) increase neurogenesis and decrease atrophy of the striatum in a transgenic mouse model for Huntington's disease.

PLoS One. 2010;5(2):e9347. PubMed: 20179764

PAPER Santello M, Volterra A

Neuroscience: Astrocytes as aide-mémoires.

Nature. 2010 Jan 14;463(7278):169-70. PubMed: 20075911

PAPER Henneberger C, Papouin T, Oliet SH, Rusakov DA

Long-term potentiation depends on release of D-serine from astrocytes.

Nature. 2010 Jan 14;463(7278):232-6. PubMed: 20075918

PAPER Corrêa DH, Ramos CH

Insights on the structure of amyloid fibrils from site-directed mutagenesis.

Protein Pept Lett. 2009;16(12):1519-25. PubMed: 20001915

PAPER Doody RS, Pavlik V, Massman P, Rountree S, Darby E, Chan W

Predicting progression of Alzheimer's disease.

Alzheimers Res Ther. 2010;2(1):2. PubMed: 20178566

PAPER Most EI, Scheltens P, Van Someren EJ

Prevention of depression and sleep disturbances in elderly with memory-problems by activation of the biological clock with light--a randomized clinical trial.

Trials. 2010;11:19. PubMed: 20178604

PAPER Si W, Zhang X, Niu Y, Yu H, Lei X, Chen H, Cao X

A novel derivative of xanomeline improves fear cognition in aged mice.

Neurosci Lett. 2010 Apr 5;473(2):115-9. PubMed: 20178835

PAPER Larner AJ

Can IQCODE differentiate Alzheimer's disease and frontotemporal dementia?

Age Ageing. 2010 May;39(3):392-4. PubMed: 20178996

PAPER Farran CJ, McCann JJ, Fogg LG, Etkin CD

Developing a Measurement Strategy for Assessing Family Caregiver Skills: Conceptual Issues.

Alzheimers care today. 2009;10(3):129-139. PubMed: 20179779