Di Wu

Sweden

Drug Brief: Generic Aricept Approval—Melts in Your Mouth?

RESEARCH NEWS 2009-12-22 Research News On 11 December 2009, the U.S. Food and Drug Administration (FDA) announced approval of a generic version of Aricept (donepezil hydrochloride), one of the first prescription drugs to be marketed for the treatment of mild to moderate Alzheimer

Toshiro Kawashima

Fukuoka Prefectural Psychiatric Center Dazaifu Hospital
Dazaifu, Japan

Joyce Goodlatte

United States

Scott Counts on Brain-derived neurotrophic factor reduces amyloidogenic processing through control of SORLA gene expression.

COMMENT The article by Rohe and colleagues presents data derived from in vivo and in vitro studies demonstrating a novel role for brain-derived neurotrophic factor (BDNF) in the induction of SORLA, which regulates intracellular trafficking and processing of APP i

Andre Delacourte on Progranulin is expressed within motor neurons and promotes neuronal cell survival.

COMMENT At last, a possible explanation for the presence of progranulin in the neurodegenerative field. 0 andre.delacourte

Andre Delacourte on Multi-Paper Alert: More Data That Brain Amyloid Is Bad for You

COMMENT All these observations of amyloid deposition in prodromal AD clearly demonstrate that amyloidosis is an early marker of a pathological process that will lead to AD dementia. Accordingly, they also demonstrate that preamyloid, oligomer deposition has not t

PAPER Gros-Louis F, Andersen PM, Dupre N, Urushitani M, Dion P, Souchon F, D'Amour M, Camu W, Meininger V, Bouchard JP, Rouleau GA, Julien JP

Chromogranin B P413L variant as risk factor and modifier of disease onset for amyotrophic lateral sclerosis.

Proc Natl Acad Sci U S A. 2009 Dec 22;106(51):21777-82. PubMed: 20007371

PAPER Brown RH

Medicine. A reinnervating microRNA.

Science. 2009 Dec 11;326(5959):1494-5. PubMed: 20007892

PAPER Williams AH, Valdez G, Moresi V, Qi X, McAnally J, Elliott JL, Bassel-Duby R, Sanes JR, Olson EN

MicroRNA-206 delays ALS progression and promotes regeneration of neuromuscular synapses in mice.

Science. 2009 Dec 11;326(5959):1549-54. PubMed: 20007902

Kim Green on Amyloid precursor protein regulates Cav1.2 L-type calcium channel levels and function to influence GABAergic short-term plasticity.

COMMENT The current study by Yang et al. shows a novel physiological role for APP in the regulation of the L-type voltage-gated calcium channel specifically in GABAergic neurons. These results highlight APP—and APP fragments—as important regulators of synaptic fu

Sang Joon Son

Korea, Republic of

bFGF (6)

ANTIBODY monoclonal 6 manufacturer Cat#<br />610073 Immunogen = full length human FGF basic liquid, buffered, BSA, glycerol, azide FGF basic, 18-24 kda by WB IgG₁ FGF & FGF Receptors BD Transduction Mouse Dog Chicken Human Mouse Ra

FGFR2 /bek (8R3AS)

ANTIBODY monoclonal 8R3AS manufacturer Cat #<br />SC-73738 immunogen = full length recombinant Bek of human origin liquid IgG, PBS, azide, protein stabilizer<br />Also azide-free, SC-73738 L detects Bek (FGFR-2); 120 kDa IgG_2b FG

FGF-R3 phos Tyr724

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