Elise Henning

Autopsy Study Confirms Flortaucipir PET Lights Up Tau Pathology

RESEARCH NEWS 2018-12-14 Research News For a PET ligand, validation is literally a matter of life and death. Its reliability rides on a direct comparison of tracer uptake in a living person with his or her autopsy result. In the December 3 JAMA Neurology, Ruben Smith and Oskar ...

Val Lowe on Autopsy Study Confirms Flortaucipir PET Lights Up Tau Pathology

COMMENT This is a brilliant study that shows us just how well Flortaucipir PET matches neuropathologically mapped tau. The correlations were strong as tested in a wide variety brain regions. The study clearly adds to our knowledge of Flortaucipir PET performance. ...

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Richard Ransohoff on Impact of Genetic Polymorphisms on Human Immune Cell Gene Expression.

COMMENT Stunning achievement, combining genome-wide SNP analysis with RNA-Seq—protein-coding; pseudogenes; lncRNAs; sncRNAs—in 13 human immune cell types, primarily lymphocytes. Once cis eQTL, i.e., SNPs that affected expression of a gene on the same chromosome, ...

Richard Ransohoff on Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes.

COMMENT Microglial scRNA-Seq was performed across the mouse life span from E14.5 through P540. After cluster analysis, care was taken to specify at what age, and where, in the brain varied clusters were detected. It was observed that maximal microglial ...

PAPER Reisberg B

Functional assessment staging (FAST).

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Subhojit Roy on Does Oleic Acid Hold the Key to α-Synuclein Toxicity?

COMMENT These are exciting findings, with implications for α-synuclein therapeutics and Parkinson's disease. Researchers have known that α-synuclein interacts with lipids for some time, but few therapeutic strategies have exploited this property. The two ...

PAPER Olah M, Menon V, Habib N, Taga M, Yung C, Cimpean M, Khairalla A, Dionne D, Hopp S, Frosch MP, Hyman BT, Beach TG, Sarkis R, Cosgrove GR, Helgager J, Golden JA, Pennell PB, Schneider JA, Bennett DA, Regev A, Elyaman W, Bradshaw EM, De Jager PL

A single cell-based atlas of human microglial states reveals associations with neurological disorders and histopathological features of the aging brain

bioRxiv. June 11, 2018