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Exercise Program Fails to Ease Dementia

RESEARCH NEWS 2018-05-26 Research News A yearlong program of brisk exercise in people with mild to moderate dementia left participants more physically fit, but no better off in terms of mental functioning, daily living, or quality of life. In fact, the intensive exercise program ...

At AAN, Sights Set on Antisense Therapies for Diseases of the Brain

CONFERENCE COVERAGE 2018-05-25 Conference Coverage In recent years, two antisense oligonucleotide therapies have hit the market, at least nine more are in clinical trials for the treatment of neurologic diseases, and nearly two dozen are in preclinical testing, including ASOs for ...

American Academy of Neurology Annual Meeting 2018

CONFERENCE COVERAGE SERIES As RNA Therapies Come of Age, Efficacy Remains Weak At AAN, Sights Set on Antisense Therapies for Diseases of the Brain Will RNA molecules that bump up or tamp down gene expression live up to their potential? Results from RNA-targeting therapies presented ...

As RNA Therapies Come of Age, Efficacy Remains Weak

CONFERENCE COVERAGE 2018-05-25 Conference Coverage Recent approvals of antisense therapies for spinal muscular atrophy and Duchenne muscular dystrophy have bolstered hopes for targeting RNA to treat a plethora of neurodegenerative brain disorders. At the 70th annual meeting of the ...

PAPER Mercuri E, Darras BT, Chiriboga CA, Day JW, Campbell C, Connolly AM, Iannaccone ST, Kirschner J, Kuntz NL, Saito K, Shieh PB, Tulinius M, Mazzone ES, Montes J, Bishop KM, Yang Q, Foster R, Gheuens S, Bennett CF, Farwell W, Schneider E, De Vivo DC, Finkel RS, CHERISH Study Group

Nusinersen versus Sham Control in Later-Onset Spinal Muscular Atrophy.

N Engl J Med. 2018 Feb 15;378(7):625-635. PubMed: 29443664

No REST for the Brainy: Human Evolution Linked to Diseases of Aging

RESEARCH NEWS 2018-05-25 Research News In evolution, there is no free lunch. In other words, a good brain exacts its price. According to a May 23 study in Cell Systems, some of the same genetic adaptations that bestowed the cerebral cortex on humans also may have opened the door ...

PAPER Andersson R, Gebhard C, Miguel-Escalada I, Hoof I, Bornholdt J, Boyd M, Chen Y, Zhao X, Schmidl C, Suzuki T, Ntini E, Arner E, Valen E, Li K, Schwarzfischer L, Glatz D, Raithel J, Lilje B, Rapin N, Bagger FO, Jørgensen M, Andersen PR, Bertin N, Rackham O, Burroughs AM, Baillie JK, Ishizu Y, Shimizu Y, Furuhata E, Maeda S, Negishi Y, Mungall CJ, Meehan TF, Lassmann T, Itoh M, Kawaji H, Kondo N, Kawai J, Lennartsson A, Daub CO, Heutink P, Hume DA, Jensen TH, Suzuki H, Hayashizaki Y, Müller F, Forrest AR, Carninci P, Rehli M, Sandelin A

An atlas of active enhancers across human cell types and tissues.

Nature. 2014 Mar 27;507(7493):455-461. PubMed: 24670763

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