RESEARCH NEWS 2018-05-26 Research News A yearlong program of brisk exercise in people with mild to moderate dementia left participants more physically fit, but no better off in terms of mental functioning, daily living, or quality of life. In fact, the intensive exercise program ...
PAPER Lamb SE, Sheehan B, Atherton N, Nichols V, Collins H, Mistry D, Dosanjh S, Slowther AM, Khan I, Petrou S, Lall R
CONFERENCE COVERAGE 2018-05-25 Conference Coverage In recent years, two antisense oligonucleotide therapies have hit the market, at least nine more are in clinical trials for the treatment of neurologic diseases, and nearly two dozen are in preclinical testing, including ASOs for ...
CONFERENCE COVERAGE SERIES As RNA Therapies Come of Age, Efficacy Remains Weak At AAN, Sights Set on Antisense Therapies for Diseases of the Brain Will RNA molecules that bump up or tamp down gene expression live up to their potential? Results from RNA-targeting therapies presented ...
CONFERENCE COVERAGE 2018-05-25 Conference Coverage Recent approvals of antisense therapies for spinal muscular atrophy and Duchenne muscular dystrophy have bolstered hopes for targeting RNA to treat a plethora of neurodegenerative brain disorders. At the 70th annual meeting of the ...
PAPER Adams D, Suhr OB, Dyck PJ, Litchy WJ, Leahy RG, Chen J, Gollob J, Coelho T
Trial design and rationale for APOLLO, a Phase 3, placebo-controlled study of patisiran in patients with hereditary ATTR amyloidosis with polyneuropathy.BMC Neurol. 2017 Sep 11;17(1):181. PubMed: 28893208
PAPER Charleston JS, Schnell FJ, Dworzak J, Donoghue C, Lewis S, Chen L, Young GD, Milici AJ, Voss J, DeAlwis U, Wentworth B, Rodino-Klapac LR, Sahenk Z, Frank D, Mendell JR29752304
PAPER Gerrity MS, Prasad V, Obley AJ29710299
PAPER King NM, Bishop CE28467402
PAPER Mercuri E, Darras BT, Chiriboga CA, Day JW, Campbell C, Connolly AM, Iannaccone ST, Kirschner J, Kuntz NL, Saito K, Shieh PB, Tulinius M, Mazzone ES, Montes J, Bishop KM, Yang Q, Foster R, Gheuens S, Bennett CF, Farwell W, Schneider E, De Vivo DC, Finkel RS, CHERISH Study Group29443664
RESEARCH NEWS 2018-05-25 Research News In evolution, there is no free lunch. In other words, a good brain exacts its price. According to a May 23 study in Cell Systems, some of the same genetic adaptations that bestowed the cerebral cortex on humans also may have opened the door ...
PAPER Iwamoto N, Butler DC, Svrzikapa N, Mohapatra S, Zlatev I, Sah DW, Meena, Standley SM, Lu G, Apponi LH, Frank-Kamenetsky M, Zhang JJ, Vargeese C, Verdine GL
Control of phosphorothioate stereochemistry substantially increases the efficacy of antisense oligonucleotides.Nat Biotechnol. 2017 Sep;35(9):845-851. Epub 2017 Aug 21 PubMed: 28829437
PAPER Andersson R, Gebhard C, Miguel-Escalada I, Hoof I, Bornholdt J, Boyd M, Chen Y, Zhao X, Schmidl C, Suzuki T, Ntini E, Arner E, Valen E, Li K, Schwarzfischer L, Glatz D, Raithel J, Lilje B, Rapin N, Bagger FO, Jørgensen M, Andersen PR, Bertin N, Rackham O, Burroughs AM, Baillie JK, Ishizu Y, Shimizu Y, Furuhata E, Maeda S, Negishi Y, Mungall CJ, Meehan TF, Lassmann T, Itoh M, Kawaji H, Kondo N, Kawai J, Lennartsson A, Daub CO, Heutink P, Hume DA, Jensen TH, Suzuki H, Hayashizaki Y, Müller F, Forrest AR, Carninci P, Rehli M, Sandelin A24670763
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