Modification: TREM2: Knock-In
Disease Relevance: Alzheimer's Disease, Frontotemporal Dementia, Nasu-Hakola Disease
Strain Name: B6(C3)-Trem2tm1c(EUCOMM)Wtsi/AdiujJ
Genetic Background: B6(C3)
Availability: The Jackson Lab: Stock# 029853; Live. (Estimated to begin distribution April 2018)
These mice possess a floxed Trem2 allele. When bred to mice expressing Cre-recombinase driven by specific promoters, offspring can be used to study the conditional knockout of Trem2.
Heterozygotes are viable and fertile; viability and fertility in homozygous mice have not yet been reported.
Targeted insertion of LoxP sites flanking exons 2 and 3 of the mouse Trem2 gene.
No Available Further Reading