Research Models

TPM (Thy-1 PS1.M146V)

Species: Mouse
Genes: PSEN1
Mutations: PSEN1 M146V
Modification: PSEN1: Transgenic
Disease Relevance: Alzheimer's Disease
Strain Name: N/A
Genetic Background: Transgene injected into fertilized oocytes from pure C57BL/6 mice.
Availability: Unknown

Summary

This transgenic mouse model was generated by scientists at GlaxoSmithKline. Reports describing the phenotypic characterization of this mouse as a single transgenic are sparse in the published literature. It is best known for being one of the parental strains used to generate the TASTPM double transgenic, which develops amyloid pathology and cognitive deficits (Howlett et al., 2004).

Modification Details

Transgene encoding human PSEN1 carrying the M146V mutation. Transgene is driven by the murine Thy-1 promoter.

Related Strains

TASTPM: A double transgenic generated by crossing the TPM model with another trangenic line, TAS10, which expresses mutant human APP.

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References

Research Models Citations

  1. TASTPM (TAS10 x TPM)
  2. TAS10 (thy1-APPswe)

Paper Citations

  1. . Cognitive correlates of Abeta deposition in male and female mice bearing amyloid precursor protein and presenilin-1 mutant transgenes. Brain Res. 2004 Aug 13;1017(1-2):130-6. PubMed.

Further Reading