Research Models

TMHT (Thy-1 mutated human tau)

Synonyms: TAU 441, hTAU441, TAU441 V337M R406W


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Species: Mouse
Genes: MAPT
Mutations: MAPT V337M (Seattle), MAPT R406W
Modification: MAPT: Transgenic
Disease Relevance: Alzheimer's Disease
Strain Name: N/A
Genetic Background: C57Bl/6xDBA
Availability: The CRO QPS-Austria offers research services with this line.


Increased total tau and phosphorylated tau species (Thr181, Ser199, Thr231) in the amygdala and hippocampus starting at three months.


Spatial memory deficits starting at five months by the Morris water maze. Olfactory deficits at five months indicated by the buried food test. No motor deficits (by rotarod, beam walk) or depressive behavior as indicated by the forced swim test.

Modification Details

Transgene consists of human MAPT Tau441 (2N/4R) with mutations V337M and R406W under control of the Thy1 promoter.


The contract research organization QPS-Austria ( offers research services with this line.

Phenotype Characterization

When visualized, these models will distributed over a 18 month timeline demarcated at the following intervals: 1mo, 3mo, 6mo, 9mo, 12mo, 15mo, 18mo+.


  • Plaques

No Data




Tangles at 4 months and progress with age.

Cognitive Impairment

Cognitive impairment by 5 months as measured by the Morris Water Maze.

Last Updated: 02 Jul 2013


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External Citations

  1. QPS-Austria
  2. QPS-Austria

Further Reading

No Available Further Reading