Amyloid pathology starting at 2 months, including amyloid plaques. Accumulation of intraneuronal Aβ before amyloid deposition. Gliosis and synapse degeneration. Neuron loss in cortical layer 5 and subiculum. No neurofibrillary tangles.
Age-dependent memory deficits including spatial memory, stress-related memory, and memory stablization. Motor phenotype.
Aggressive amyloidosis with deposition in the cortex beginning at 2 months and approaching saturation by 7 months. Aβ deposition in heterozygous mice at 4 months. Subcortical amyloidosis. Exacerbated microgliosis and astrocytosis compared to APPNL-F mice. Reduced synaptophysin and PSD-95 indicative of synaptic loss. No tangle pathology or neurodegeneration.
Memory impairment by 6 months as measured by the Y maze.
Yes
C57BL/6
Apptm3.1Tcs/Apptm3.1Tcs
No overexpression of APP. Wild-type levels of AICD.
