Research Models
Selected Results
1 Models
| Name | Other Names | Strain Name | Genetic Background | Gene | Mutation | Modification Info | Modification | Disease | Neuropathology | Behavior/Cognition | Other Phenotype | Availability | Primary Paper | Visualization | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mouse Models (1) |
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| C57BL/6J-Trem2em3Adiuj/J | C57BL/6J | Trem2 | TREM2 Y38C | CRISPR/Cas9 was used to introduce a point mutation into the endogenous mouse Trem2 gene, resulting in a tyrosine-to-cysteine amino acid substitution at amino acid 38 (Y38C). | Trem2: Knock-In | Frontotemporal Dementia | No data. | No data. | The Jackson Lab: Stock# 029725; Cryopreserved | Yes | |||||
1 Visualizations
AD-related Research Models
Phenotypes Examined
- Plaques
- Tangles
- Neuronal Loss
- Gliosis
- Synaptic Loss
- Changes in LTP/LTD
- Cognitive Impairment
When visualized, these phenotypes will distributed over a 18 month timeline demarcated at the following intervals: 3mo, 6mo, 9mo, 1yr, 15mo, 18mo+.
Trem2 Y38C KI
Observed
Absent
No Data
-
Plaques at
No data.
-
Tangles at
No data.
-
Neuronal Loss at
No data.
-
Gliosis at
No data.
-
Synaptic Loss at
No data.
-
Changes in LTP/LTD at
No data.
-
Cognitive Impairment at
No data.
| Genes | Mutations | Modification | Disease | Neuropathology | Behavior/Cognition |
|---|---|---|---|---|---|
| Trem2 | TREM2 Y38C | Trem2: Knock-In | Frontotemporal Dementia | No data. |
No data. |