Research Models

Selected Results

1 Models

Name Other Names Strain Name Genetic Background Gene Mutation Modification Info Modification Disease Neuropathology Behavior/Cognition Other Phenotype Availability Primary Paper Visualization
Mouse Models (1)
Trem2 p.T66M Trem2em1Bwef Mixed DBA/2J, FVB/ N, C57BL/6J Trem2 TREM2 T66M A CA>TG substitution was introduced into the murine Trem2 gene using CRISPR/Cas9 genome editing, resulting in a threonine-to-methionine substitution at amino acid 66.. Trem2: Knock-In Frontotemporal Dementia Age-related microglial activation seen in wild-type mice is absent in homozygotes. No data. Reduced cerebral blood flow and reduced cerebral glucose metabolism in homozygotes. Bone marrow-derived macrophages from heterozygous and homozygous Trem2 T66M mice show reduced proliferation, survival, and phagocytosis. Available through Christian Haass Kleinberger et al., 2017 Yes

1 Visualizations

AD-related Research Models

Phenotypes Examined

  • Plaques
  • Tangles
  • Neuronal Loss
  • Gliosis
  • Synaptic Loss
  • Changes in LTP/LTD
  • Cognitive Impairment

When visualized, these phenotypes will distributed over a 18 month timeline demarcated at the following intervals: 3mo, 6mo, 9mo, 1yr, 15mo, 18mo+.

Trem2 T66M KI

Observed
  1. X
    Gliosis at 30

    Fewer clusters of Iba1-immunoreactive microglia in Trem2 T66M mice compared with wild-type mice, becoming statistically significant at 7 months of age.

Absent
  • Plaques at

    Not observed.

  • Tangles at

    Not observed.

No Data
  • Neuronal Loss at

    No data.

  • Synaptic Loss at

    No data.

  • Changes in LTP/LTD at

    No data.

  • Cognitive Impairment at

    No data.

Genes Mutations Modification Disease Neuropathology Behavior/Cognition
Trem2 TREM2 T66M Trem2: Knock-In Frontotemporal Dementia

Age-related microglial activation seen in wild-type mice is absent in homozygotes.

No data.

expand