Research Models

Selected Results

1 Models

Name Other Names Strain Name Genetic Background Gene Mutation Modification Info Modification Disease Neuropathology Behavior/Cognition Other Phenotype Availability Primary Paper Visualization
Rat Models (1)
Psen1LF Long-Evans Psen1, App PSEN1 L435F Rats carry a mutation in the endogenous Psen1 gene that is homologous to the human L435F mutation, as well as a humanized Aβ sequence within the endogenous App gene. Psen1: Knock-In; App: Knock-In Alzheimer's Disease None observed in 15-day-old rats. Unknown. Levels of Aβ43 are elevated in the brains of homozygous and heterozygous Psen1 mutation carriers. Available through Luciano D’Adamio. Tambini and D'Adamio, 2020 Yes

1 Visualizations

AD-related Research Models

Phenotypes Examined

  • Plaques
  • Tangles
  • Neuronal Loss
  • Gliosis
  • Synaptic Loss
  • Changes in LTP/LTD
  • Cognitive Impairment

When visualized, these phenotypes will distributed over a 18 month timeline demarcated at the following intervals: 3mo, 6mo, 9mo, 1yr, 15mo, 18mo+.

Psen1 L435F knock-in

Observed
Absent
  • Plaques at

    No plaques at 15 days of age.

  • Neuronal Loss at

    No neuron loss at 15 days of age.

  • Gliosis at

    No astrogliosis or microgliosis at 15 days of age.

No Data
  • Tangles at

    No data. 

  • Synaptic Loss at

    No data.

  • Changes in LTP/LTD at

    No data.

  • Cognitive Impairment at

    No data.

Genes Mutations Modification Disease Neuropathology Behavior/Cognition
Psen1, App PSEN1 L435F Psen1: Knock-In; App: Knock-In Alzheimer's Disease

None observed in 15-day-old rats.

Unknown.

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