|Name||Other Names||Strain Name||Genetic Background||Gene||Mutation||Modification Info||Modification||Disease||Neuropathology||Behavior/Cognition||Other Phenotype||Availability||Primary Paper||Visualization|
Mouse Models (1)
|B6.Cg-Tg(Thy1-APP)3Somm/J; Psen1tm1.1Tcs||C57BL/6J||APP, PSEN1||PSEN1 R278I||This is a cross between APP23 mice, which overexpress APP751 with the Swedish mutation driven by the murine Thy1 promoter, and PSEN1 knock-in mice expressing human PSEN1 with the R278I mutation under the endogenous promoter.||APP: Transgenic; PSEN1: Knock-In||Alzheimer's Disease||Amyloid deposition by 6 months of age in the cortex and hippocampus. Abundant reactive astrocytes in the vicinity of plaques. Elevated Aβ43 in the brain by 3 months. High density of cored plaques. Pyroglutamate Aβ (N3pE-Aβ) associated with amyloid plaques.||Short-term memory deficits apparent by 3-4 months as measured by the Y maze.||Reduced γ-secretase activity.||Available through Takaomi Saido||Saito et al., 2011||Yes|
AD-related Research Models
- Neuronal Loss
- Synaptic Loss
- Changes in LTP/LTD
- Cognitive Impairment
When visualized, these phenotypes will distributed over a 18 month timeline demarcated at the following intervals: 3mo, 6mo, 9mo, 1yr, 15mo, 18mo+.
Plaques at 26
By 6 months of age amyloid plaques accumulate in the cortex and hippocampus. A high percentage of plaques are thioflavin-S –positive cored plaques.
Gliosis at 39
Astrocytosis in the vicinity of plaques in the hippocampus and cortex by 9 months.
Cognitive Impairment at 13
Short-term memory deficits are apparent by 3 to 4 months as measured by the Y maze.
Neuronal Loss at
Synaptic Loss at
Changes in LTP/LTD at
|APP, PSEN1||PSEN1 R278I||APP: Transgenic; PSEN1: Knock-In||Alzheimer's Disease||
Amyloid deposition by 6 months of age in the cortex and hippocampus. Abundant reactive astrocytes in the vicinity of plaques. Elevated Aβ43 in the brain by 3 months. High density of cored plaques. Pyroglutamate Aβ (N3pE-Aβ) associated with amyloid plaques.
Short-term memory deficits apparent by 3-4 months as measured by the Y maze.