|Name||Other Names||Strain Name||Genetic Background||Gene||Mutation||Modification Info||Modification||Disease||Neuropathology||Behavior/Cognition||Other Phenotype||Availability||Primary Paper||Visualization|
Rat Models (1)
|Psen1LF||Long-Evans||Psen1, App||PSEN1 L435F||Rats carry a mutation in the endogenous Psen1 gene that is homologous to the human L435F mutation, as well as a humanized Aβ sequence within the endogenous App gene.||Psen1: Knock-In; App: Knock-In||Alzheimer's Disease||None observed in 15-day-old rats.||Unknown.||Levels of Aβ43 are elevated in the brains of homozygous and heterozygous Psen1 mutation carriers.||Available through Luciano D’Adamio.||Tambini and D'Adamio, 2020||Yes|
AD-related Research Models
- Neuronal Loss
- Synaptic Loss
- Changes in LTP/LTD
- Cognitive Impairment
When visualized, these phenotypes will distributed over a 18 month timeline demarcated at the following intervals: 3mo, 6mo, 9mo, 1yr, 15mo, 18mo+.
No plaques at 15 days of age.
Neuronal Loss at
No neuron loss at 15 days of age.
No astrogliosis or microgliosis at 15 days of age.
Synaptic Loss at
Changes in LTP/LTD at
Cognitive Impairment at
|Psen1, App||PSEN1 L435F||Psen1: Knock-In; App: Knock-In||Alzheimer's Disease||
None observed in 15-day-old rats.