Mutations: PSEN2 N141I
Modification: PSEN2: Transgenic
Disease Relevance: Alzheimer's Disease
Strain Name: N/A
Genetic Background: C57BL/6× DBA/2
Transgene containing human PSEN2 carrying the N141I mutation driven by the neuron-specific enolase (NSE) promoter.
Behavioral deficits in the water maze at 12 months in mice expressing mutant as well as wild-type PSEN2, including longer escape latencies than wild-type mice, but no difference in swimming speed.
Expression of PSEN2 was higher in mice expressing mutant as well as wild-type PSEN2 compared to age-matched, non-transgenic mice. Alterations in levels of Aβ42, caspase-3 and Cox-2 proteins.
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