Research Models

APOE3 Knock-In (JAX)

Synonyms: APOE3 KI, APOE*3 KI

Species: Mouse
Genes: APOE
Modification: APOE: Knock-In
Disease Relevance: Alzheimer's Disease
Strain Name: B6(SJL)-ApoEem2(APOE*)Adiuj/J
Genetic Background: B6SJL
Availability: The Jackson Laboratory, Stock # 029018; Live

Summary

APOE3 knock-in mice express humanized APOE3 from the endogenous ApoE locus.

Homozygotes are viable and fertile.

Modification Details

APOE3 knock-in mice were generated by using CRISPR/Cas9 gene editing to introduce a point mutation (leading to an arginine-to-cysteine substitution at amino acid 130) into an existing humanized APOE isoform 4 knock-in allele (ApoEtm1.1(APOE*4)Adiuj).

Related Strains

APOE4 Knock-In (JAX). APOE4 knock-in mice express a humanized APOE4 allele from the endogenous ApoE locus.

Phenotype Characterization

When visualized, these models will distributed over a 18 month timeline demarcated at the following intervals: 1mo, 3mo, 6mo, 9mo, 12mo, 15mo, 18mo+.

Absent

No Data

  • Plaques
  • Tangles
  • Neuronal Loss
  • Gliosis
  • Synaptic Loss
  • Changes in LTP/LTD
  • Cognitive Impairment

Plaques

No data.

Tangles

No data.

Neuronal Loss

No data.

Gliosis

No data.

Synaptic Loss

No data.

Changes in LTP/LTD

No data.

Cognitive Impairment

No data.

Last Updated: 29 Nov 2018

COMMENTS / QUESTIONS

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References

Other Citations

  1. ApoEtm1.1(APOE*4)Adiuj

External Citations

  1. The Jackson Laboratory, Stock # 029018

Further Reading

No Available Further Reading