Modification: APOE: Knock-In
Disease Relevance: Alzheimer's Disease
Strain Name: B6(SJL)-ApoEem2(APOE*)Adiuj/J
Genetic Background: B6SJL
Availability: The Jackson Laboratory, Stock # 029018; Live
APOE3 knock-in mice express humanized APOE3 from the endogenous ApoE locus.
Homozygotes are viable and fertile.
APOE3 knock-in mice were generated by using CRISPR/Cas9 gene editing to introduce a point mutation (leading to an arginine-to-cysteine substitution at amino acid 130) into an existing humanized APOE isoform 4 knock-in allele (ApoEtm1.1(APOE*4)Adiuj).
APOE4 Knock-In (JAX). APOE4 knock-in mice express a humanized APOE4 allele from the endogenous ApoE locus.
When visualized, these models will distributed over a 18 month timeline demarcated at the following intervals: 1mo, 3mo, 6mo, 9mo, 12mo, 15mo, 18mo+.
- Neuronal Loss
- Synaptic Loss
- Changes in LTP/LTD
- Cognitive Impairment
Changes in LTP/LTD
Last Updated: 29 Nov 2018
No Available Further Reading